Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | METTL18 | methyltransferase like 18; Probable histidine methyltransferase (By similarity) (372 aa) | ||||||||||||
Predicted Functional Partners:
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 | METTL21C | methyltransferase like 21C; Protein-lysine methyltransferase (264 aa) |
 |
0.732 | ||||||||||
 | GRWD1 | glutamate-rich WD repeat containing 1 (446 aa) |
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0.720 | ||||||||
 | METTL20 | methyltransferase like 20; Probable methyltransferase (By similarity) (262 aa) |
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0.671 | ||||||||||
 | METTL23 | methyltransferase like 23; Probable methyltransferase (By similarity) (190 aa) |
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0.612 | ||||||||||
 | METTL22 | methyltransferase like 22; Probable methyltransferase (By similarity) (404 aa) |
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0.601 | ||||||||||
 | METTL21B | methyltransferase like 21B; Protein-lysine methyltransferase (By similarity) (226 aa) |
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0.596 | ||||||||||
 | GALNT14 | UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (552 aa) |
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0.584 | ||||||||||
 | METTL21A | methyltransferase like 21A; Protein-lysine methyltransferase (218 aa) |
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0.583 | ||||||||||
 | RPL3 | ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes (403 aa) |
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0.508 | |||||||||
 | FAM86B1 | family with sequence similarity 86, member B1 (330 aa) |
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0.485 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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