| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CADM1 | DONSON | ENSP00000395359 | ENSP00000307143 | cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachme [...] | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.564 |
| CIB2 | COPB2 | ENSP00000258930 | ENSP00000329419 | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.597 |
| CIB2 | DONSON | ENSP00000258930 | ENSP00000307143 | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.581 |
| COPB2 | CIB2 | ENSP00000329419 | ENSP00000258930 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | 0.597 |
| COPB2 | DONSON | ENSP00000329419 | ENSP00000307143 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.563 |
| COPB2 | GOLPH3 | ENSP00000329419 | ENSP00000265070 | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene | 0.572 |
| DNA2 | DONSON | ENSP00000382133 | ENSP00000307143 | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.584 |
| DONSON | CADM1 | ENSP00000307143 | ENSP00000395359 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachme [...] | 0.564 |
| DONSON | CIB2 | ENSP00000307143 | ENSP00000258930 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | calcium and integrin binding family member 2; Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process (By similarity) | 0.581 |
| DONSON | COPB2 | ENSP00000307143 | ENSP00000329419 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.563 |
| DONSON | DNA2 | ENSP00000307143 | ENSP00000382133 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | DNA replication helicase 2 homolog (yeast); Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1- flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5’-end resection of DNA during double- strand break (DSB) repair- recruited by BLM and mediates the cleavage of 5’-ssDNA, while the 3’-ssDNA cleavage is prev [...] | 0.584 |
| DONSON | GART | ENSP00000307143 | ENSP00000371236 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.810 |
| DONSON | GOLPH3 | ENSP00000307143 | ENSP00000265070 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene | 0.566 |
| DONSON | MB21D2 | ENSP00000307143 | ENSP00000376246 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | Mab-21 domain containing 2 | 0.608 |
| DONSON | MCM3 | ENSP00000307143 | ENSP00000229854 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | minichromosome maintenance complex component 3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | 0.554 |
| DONSON | NDUFS3 | ENSP00000307143 | ENSP00000263774 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.570 |
| DONSON | SON | ENSP00000307143 | ENSP00000348984 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | SON DNA binding protein | 0.565 |
| GART | DONSON | ENSP00000371236 | ENSP00000307143 | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.810 |
| GOLPH3 | COPB2 | ENSP00000265070 | ENSP00000329419 | golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene | coatomer protein complex, subunit beta 2 (beta prime); The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding [...] | 0.572 |
| GOLPH3 | DONSON | ENSP00000265070 | ENSP00000307143 | golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.566 |
Share
