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STRINGSTRING
ATP2B2 ATP2B2 ATP2B1 ATP2B1 RYR2 RYR2 ATP2B3 ATP2B3 PKP2 PKP2 DSP DSP KRT74 KRT74 JUP JUP FOS FOS LIPH LIPH LPAR6 LPAR6
"KRT74" - keratin 74 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining
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co-expression
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protein homology
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[Homology]
Score
KRT74keratin 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (529 aa)    
Predicted Functional Partners:
JUP
junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
            score_image   0.873
LPAR6
lysophosphatidic acid receptor 6 (344 aa)
            score_image   0.861
LIPH
lipase, member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (451 aa)
            score_image   0.860
DSP
desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes (2871 aa)
            score_image   0.815
FOS
FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] (380 aa)
            score_image   0.803
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (1220 aa)
            score_image   0.801
RYR2
ryanodine receptor 2 (cardiac); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (4967 aa)
            score_image   0.771
PKP2
plakophilin 2; May play a role in junctional plaques (881 aa)
            score_image   0.757
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (1243 aa)
            score_image   0.739
ATP2B3
ATPase, Ca++ transporting, plasma membrane 3 (1220 aa)
            score_image   0.739
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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