Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
TNNI3 TNNI3 TNNC2 TNNC2 TPM2 TPM2 TNNI2 TNNI2 MYH3 MYH3 MYH8 MYH8 TNNI1 TNNI1 MYH6 MYH6 TNNT3 TNNT3 MYL1 MYL1 MYOD1 MYOD1
"MYL1" - myosin, light chain 1, alkali in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYL1myosin, light chain 1, alkali; skeletal, fast; Regulatory light chain of myosin. Does not bind calcium (194 aa)    
Predicted Functional Partners:
TNNI2
troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (182 aa)
      score_image score_image score_image score_image   0.975
TNNC2
troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments (160 aa)
      score_image   score_image score_image score_image 0.973
TNNT3
troponin T type 3 (skeletal, fast) (258 aa)
      score_image score_image score_image score_image   0.972
MYH6
myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa)
      score_image score_image score_image score_image   0.968
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa)
      score_image score_image score_image score_image   0.962
TNNI1
troponin I type 1 (skeletal, slow) (187 aa)
      score_image score_image score_image score_image   0.958
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction (1937 aa)
      score_image score_image score_image score_image   0.958
MYOD1
myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) (320 aa)
      score_image   score_image score_image   0.949
TPM2
tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) (284 aa)
      score_image score_image score_image score_image   0.945
TNNI3
troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (210 aa)
      score_image score_image score_image score_image   0.945
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (33%)