node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYH3 | MYH6 | ENSP00000226209 | ENSP00000348634 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | 0.900 |
MYH3 | MYH8 | ENSP00000226209 | ENSP00000384330 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.900 |
MYH3 | MYL1 | ENSP00000226209 | ENSP00000307280 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myosin, light chain 1, alkali; skeletal, fast; Regulatory light chain of myosin. Does not bind calcium | 0.962 |
MYH3 | MYOD1 | ENSP00000226209 | ENSP00000250003 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.828 |
MYH3 | TNNC2 | ENSP00000226209 | ENSP00000361636 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.975 |
MYH3 | TNNI1 | ENSP00000226209 | ENSP00000337022 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 1 (skeletal, slow) | 0.977 |
MYH3 | TNNI2 | ENSP00000226209 | ENSP00000252898 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.994 |
MYH3 | TNNI3 | ENSP00000226209 | ENSP00000341838 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.971 |
MYH3 | TNNT3 | ENSP00000226209 | ENSP00000278317 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | troponin T type 3 (skeletal, fast) | 0.991 |
MYH3 | TPM2 | ENSP00000226209 | ENSP00000354219 | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.987 |
MYH6 | MYH3 | ENSP00000348634 | ENSP00000226209 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.900 |
MYH6 | MYH8 | ENSP00000348634 | ENSP00000384330 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction | 0.900 |
MYH6 | MYL1 | ENSP00000348634 | ENSP00000307280 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | myosin, light chain 1, alkali; skeletal, fast; Regulatory light chain of myosin. Does not bind calcium | 0.968 |
MYH6 | MYOD1 | ENSP00000348634 | ENSP00000250003 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.983 |
MYH6 | TNNC2 | ENSP00000348634 | ENSP00000361636 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments | 0.970 |
MYH6 | TNNI1 | ENSP00000348634 | ENSP00000337022 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin I type 1 (skeletal, slow) | 0.984 |
MYH6 | TNNI2 | ENSP00000348634 | ENSP00000252898 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.978 |
MYH6 | TNNI3 | ENSP00000348634 | ENSP00000341838 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity | 0.991 |
MYH6 | TNNT3 | ENSP00000348634 | ENSP00000278317 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | troponin T type 3 (skeletal, fast) | 0.976 |
MYH6 | TPM2 | ENSP00000348634 | ENSP00000354219 | myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction | tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) | 0.973 |