node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFF1 | CLP1 | ENSP00000378578 | ENSP00000434995 | AF4/FMR2 family, member 1 | cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] | 0.414 |
AFF1 | DOT1L | ENSP00000378578 | ENSP00000381657 | AF4/FMR2 family, member 1 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | 0.942 |
AFF1 | MLLT1 | ENSP00000378578 | ENSP00000252674 | AF4/FMR2 family, member 1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.999 |
AFF1 | MLLT10 | ENSP00000378578 | ENSP00000307411 | AF4/FMR2 family, member 1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10; Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA | 0.868 |
AFF1 | MLLT3 | ENSP00000378578 | ENSP00000369695 | AF4/FMR2 family, member 1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.999 |
AFF1 | MLLT4 | ENSP00000378578 | ENSP00000375956 | AF4/FMR2 family, member 1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.648 |
CLP1 | AFF1 | ENSP00000434995 | ENSP00000378578 | cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] | AF4/FMR2 family, member 1 | 0.414 |
CLP1 | MLLT1 | ENSP00000434995 | ENSP00000252674 | cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.496 |
CLP1 | MLLT10 | ENSP00000434995 | ENSP00000307411 | cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10; Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA | 0.750 |
CLP1 | MLLT3 | ENSP00000434995 | ENSP00000369695 | cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.525 |
CTNNB1 | DOT1L | ENSP00000344456 | ENSP00000381657 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | 0.803 |
CTNNB1 | MLLT10 | ENSP00000344456 | ENSP00000307411 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10; Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA | 0.876 |
CTNNB1 | MLLT4 | ENSP00000344456 | ENSP00000375956 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.810 |
CTNNB1 | YEATS4 | ENSP00000344456 | ENSP00000247843 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | YEATS domain containing 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.419 |
DOT1L | AFF1 | ENSP00000381657 | ENSP00000378578 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | AF4/FMR2 family, member 1 | 0.942 |
DOT1L | CTNNB1 | ENSP00000381657 | ENSP00000344456 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | 0.803 |
DOT1L | MLLT1 | ENSP00000381657 | ENSP00000252674 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.993 |
DOT1L | MLLT10 | ENSP00000381657 | ENSP00000307411 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10; Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA | 0.996 |
DOT1L | MLLT3 | ENSP00000381657 | ENSP00000369695 | DOT1-like, histone H3 methyltransferase (S. cerevisiae); Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | 0.999 |
MLLT1 | AFF1 | ENSP00000252674 | ENSP00000378578 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA | AF4/FMR2 family, member 1 | 0.999 |