| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HDC | IMMP2L | ENSP00000267845 | ENSP00000329553 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | 0.608 |
| HDC | NPTX1 | ENSP00000267845 | ENSP00000307549 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | 0.643 |
| HDC | SLITRK1 | ENSP00000267845 | ENSP00000366288 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | SLIT and NTRK-like family, member 1; Enhances neuronal dendrite outgrowth | 0.606 |
| HDC | SLITRK2 | ENSP00000267845 | ENSP00000359521 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | SLIT and NTRK-like family, member 2; Suppresses neurite outgrowth (By similarity) | 0.681 |
| HDC | TBCD | ENSP00000267845 | ENSP00000347719 | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | tubulin folding cofactor D | 0.609 |
| IMMP2L | HDC | ENSP00000329553 | ENSP00000267845 | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | 0.608 |
| IMMP2L | NPTX1 | ENSP00000329553 | ENSP00000307549 | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | 0.610 |
| IMMP2L | SLITRK1 | ENSP00000329553 | ENSP00000366288 | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | SLIT and NTRK-like family, member 1; Enhances neuronal dendrite outgrowth | 0.564 |
| IMMP2L | SLITRK2 | ENSP00000329553 | ENSP00000359521 | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | SLIT and NTRK-like family, member 2; Suppresses neurite outgrowth (By similarity) | 0.662 |
| IMMP2L | TBCD | ENSP00000329553 | ENSP00000347719 | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | tubulin folding cofactor D | 0.607 |
| NADKD1 | NPTX1 | ENSP00000371362 | ENSP00000307549 | NAD kinase domain containing 1; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | 0.644 |
| NIT2 | NPTX1 | ENSP00000377696 | ENSP00000307549 | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | 0.924 |
| NIT2 | OPA1 | ENSP00000377696 | ENSP00000354681 | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | optic atrophy 1 (autosomal dominant); Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space | 0.644 |
| NPTX1 | HDC | ENSP00000307549 | ENSP00000267845 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine | 0.643 |
| NPTX1 | IMMP2L | ENSP00000307549 | ENSP00000329553 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | 0.610 |
| NPTX1 | NADKD1 | ENSP00000307549 | ENSP00000371362 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | NAD kinase domain containing 1; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo | 0.644 |
| NPTX1 | NIT2 | ENSP00000307549 | ENSP00000377696 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | 0.924 |
| NPTX1 | OPA1 | ENSP00000307549 | ENSP00000354681 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | optic atrophy 1 (autosomal dominant); Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space | 0.974 |
| NPTX1 | RCN2 | ENSP00000307549 | ENSP00000378349 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | reticulocalbin 2, EF-hand calcium binding domain; Not known. Binds calcium | 0.890 |
| NPTX1 | SLITRK1 | ENSP00000307549 | ENSP00000366288 | neuronal pentraxin I; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses (By similarity) | SLIT and NTRK-like family, member 1; Enhances neuronal dendrite outgrowth | 0.607 |
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