Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MORN4 | MORN repeat containing 4 (146 aa) | ||||||||||||
Predicted Functional Partners:
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 | MYO3B | myosin IIIB (1341 aa) |
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0.783 | |||||||||
 | MYO3A | myosin IIIA; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (1616 aa) |
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0.783 | |||||||||
 | GMPS | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa) |
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0.701 | ||||||||||
 | NMNAT2 | nicotinamide nucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides [...] (307 aa) |
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0.547 | ||||||||||
 | BEND3 | BEN domain containing 3 (828 aa) |
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0.543 | ||||||||||
 | NYAP2 | neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity) (653 aa) |
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0.543 | ||||||||||
 | SARM1 | sterile alpha and TIR motif containing 1 (690 aa) |
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0.531 | ||||||||||
 | HMMR | hyaluronan-mediated motility receptor (RHAMM); Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity (725 aa) |
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0.483 | ||||||||||
 | ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating ’Lys-48’-linked polyubiquitination and subsequent degradation of AKT1 in axons- degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation [...] (227 aa) |
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0.438 | ||||||||||
 | CRTAC1 | cartilage acidic protein 1 (661 aa) |
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0.400 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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