Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TSPAN5 | tetraspanin 5 (268 aa) | ||||||||||||
Predicted Functional Partners:
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 | ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa) |
 |
0.660 | ||||||||||
 | TSPAN31 | tetraspanin 31 (210 aa) |
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0.645 | ||||||||||
 | EPB49 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway (405 aa) |
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0.509 | ||||||||||
 | WDR70 | WD repeat domain 70 (654 aa) |
|
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0.414 | |||||||||
 | TSPAN13 | tetraspanin 13 (204 aa) |
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0.400 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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