| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | ASB3 | ENSP00000083182 | ENSP00000313756 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | ankyrin repeat and SOCS box containing 3 | 0.657 |
| APPBP2 | FEM1B | ENSP00000083182 | ENSP00000307298 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | 0.535 |
| APPBP2 | KLHDC2 | ENSP00000083182 | ENSP00000298307 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.609 |
| APPBP2 | KLHDC3 | ENSP00000083182 | ENSP00000313995 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | kelch domain containing 3; May be involved in meiotic recombination process | 0.630 |
| APPBP2 | LRR1 | ENSP00000083182 | ENSP00000298288 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | leucine rich repeat protein 1; May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.633 |
| APPBP2 | MED8 | ENSP00000083182 | ENSP00000290663 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | mediator complex subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 [...] | 0.658 |
| APPBP2 | PCMTD2 | ENSP00000083182 | ENSP00000307854 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.629 |
| APPBP2 | TULP4 | ENSP00000083182 | ENSP00000356064 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | tubby like protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | 0.528 |
| ASB3 | APPBP2 | ENSP00000313756 | ENSP00000083182 | ankyrin repeat and SOCS box containing 3 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.657 |
| ASB3 | KLHDC2 | ENSP00000313756 | ENSP00000298307 | ankyrin repeat and SOCS box containing 3 | kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.620 |
| ASB3 | KLHDC3 | ENSP00000313756 | ENSP00000313995 | ankyrin repeat and SOCS box containing 3 | kelch domain containing 3; May be involved in meiotic recombination process | 0.646 |
| ASB3 | PCMTD2 | ENSP00000313756 | ENSP00000307854 | ankyrin repeat and SOCS box containing 3 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.648 |
| ASB3 | TULP4 | ENSP00000313756 | ENSP00000356064 | ankyrin repeat and SOCS box containing 3 | tubby like protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) | 0.559 |
| FEM1B | APPBP2 | ENSP00000307298 | ENSP00000083182 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.535 |
| FEM1B | KLHDC2 | ENSP00000307298 | ENSP00000298307 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.563 |
| FEM1B | KLHDC3 | ENSP00000307298 | ENSP00000313995 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | kelch domain containing 3; May be involved in meiotic recombination process | 0.579 |
| FEM1B | LRR1 | ENSP00000307298 | ENSP00000298288 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | leucine rich repeat protein 1; May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.678 |
| FEM1B | MED8 | ENSP00000307298 | ENSP00000290663 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | mediator complex subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 [...] | 0.661 |
| FEM1B | PCMTD2 | ENSP00000307298 | ENSP00000307854 | fem-1 homolog b (C. elegans); Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.536 |
| KLHDC2 | APPBP2 | ENSP00000298307 | ENSP00000083182 | kelch domain containing 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.609 |
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