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LRRK1 LRRK1 LRRK2 LRRK2 EIF4EBP3 EIF4EBP3 EIF4G3 EIF4G3 EIF4G2 EIF4G2 EIF4E EIF4E EIF4A1 EIF4A1 MTOR MTOR EIF4E2 EIF4E2 EIF4G1 EIF4G1 EIF4A2 EIF4A2
"EIF4EBP3" - eukaryotic translation initiation factor 4E binding protein 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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protein homology
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EIF4EBP3eukaryotic translation initiation factor 4E binding protein 3; Regulates eIF4E activity by preventing its assembly into the eIF4F complex (100 aa)    
Predicted Functional Partners:
EIF4E
eukaryotic translation initiation factor 4E; Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (248 aa)
        score_image score_image score_image   0.999
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome (1606 aa)
          score_image score_image   0.973
EIF4A1
eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (406 aa)
          score_image score_image   0.970
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (1591 aa)
          score_image score_image   0.953
LRRK1
leucine-rich repeat kinase 1 (2015 aa)
        score_image   score_image   0.930
LRRK2
leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
        score_image   score_image   0.926
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2 (907 aa)
          score_image score_image   0.918
EIF4A2
eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (407 aa)
          score_image score_image   0.910
MTOR
mechanistic target of rapamycin (serine/threonine kinase); Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initi [...] (2549 aa)
        score_image   score_image   0.907
EIF4E2
eukaryotic translation initiation factor 4E family member 2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (245 aa)
        score_image   score_image   0.868
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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