node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAU | MEN1 | ENSP00000431822 | ENSP00000337088 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | multiple endocrine neoplasia I | 0.742 |
FAU | TM7SF2 | ENSP00000431822 | ENSP00000279263 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.695 |
FAU | UBC | ENSP00000431822 | ENSP00000344818 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | ubiquitin C | 0.887 |
FAU | ZNHIT2 | ENSP00000431822 | ENSP00000308548 | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | zinc finger, HIT-type containing 2 | 0.607 |
MEN1 | FAU | ENSP00000337088 | ENSP00000431822 | multiple endocrine neoplasia I | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.742 |
MEN1 | TM7SF2 | ENSP00000337088 | ENSP00000279263 | multiple endocrine neoplasia I | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.589 |
MEN1 | UBC | ENSP00000337088 | ENSP00000344818 | multiple endocrine neoplasia I | ubiquitin C | 0.765 |
MEN1 | ZNHIT2 | ENSP00000337088 | ENSP00000308548 | multiple endocrine neoplasia I | zinc finger, HIT-type containing 2 | 0.518 |
MOGAT3 | VPS36 | ENSP00000223114 | ENSP00000367299 | monoacylglycerol O-acyltransferase 3; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes | vacuolar protein sorting 36 homolog (S. cerevisiae); Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II compl [...] | 0.974 |
MOGAT3 | ZNHIT2 | ENSP00000223114 | ENSP00000308548 | monoacylglycerol O-acyltransferase 3; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes | zinc finger, HIT-type containing 2 | 0.915 |
PRF1 | ZNHIT2 | ENSP00000316746 | ENSP00000308548 | perforin 1 (pore forming protein); Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes | zinc finger, HIT-type containing 2 | 0.787 |
SERPINB5 | ZNHIT2 | ENSP00000372221 | ENSP00000308548 | serpin peptidase inhibitor, clade B (ovalbumin), member 5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity | zinc finger, HIT-type containing 2 | 0.661 |
TM7SF2 | FAU | ENSP00000279263 | ENSP00000431822 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.695 |
TM7SF2 | MEN1 | ENSP00000279263 | ENSP00000337088 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | multiple endocrine neoplasia I | 0.589 |
TM7SF2 | ZNHIT2 | ENSP00000279263 | ENSP00000308548 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | zinc finger, HIT-type containing 2 | 0.813 |
TXNDC5 | UBC | ENSP00000369081 | ENSP00000344818 | thioredoxin domain containing 5 (endoplasmic reticulum); Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity) | ubiquitin C | 0.846 |
TXNDC5 | ZNHIT2 | ENSP00000369081 | ENSP00000308548 | thioredoxin domain containing 5 (endoplasmic reticulum); Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity) | zinc finger, HIT-type containing 2 | 0.644 |
UBC | FAU | ENSP00000344818 | ENSP00000431822 | ubiquitin C | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.887 |
UBC | MEN1 | ENSP00000344818 | ENSP00000337088 | ubiquitin C | multiple endocrine neoplasia I | 0.765 |
UBC | TXNDC5 | ENSP00000344818 | ENSP00000369081 | ubiquitin C | thioredoxin domain containing 5 (endoplasmic reticulum); Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity) | 0.846 |