| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKS1A | SCUBE3 | ENSP00000353518 | ENSP00000274938 | ankyrin repeat and sterile alpha motif domain containing 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity) | signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | 0.530 |
| ANKS1A | TCP11 | ENSP00000353518 | ENSP00000308708 | ankyrin repeat and sterile alpha motif domain containing 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity) | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.485 |
| ANKS1A | ZNF76 | ENSP00000353518 | ENSP00000363064 | ankyrin repeat and sterile alpha motif domain containing 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity) | zinc finger protein 76; May be involved in transcriptional regulation | 0.512 |
| DPEP3 | TCP11 | ENSP00000268793 | ENSP00000308708 | dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity) | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.428 |
| FBXW9 | TCP11 | ENSP00000376945 | ENSP00000308708 | F-box and WD repeat domain containing 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.623 |
| FIG4 | TCP11 | ENSP00000230124 | ENSP00000308708 | FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.438 |
| OTUB1 | TCP11 | ENSP00000402551 | ENSP00000308708 | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.416 |
| OTUB2 | TCP11 | ENSP00000203664 | ENSP00000308708 | OTU domain, ubiquitin aldehyde binding 2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains, with a preference for ’Lys-63’-linked polyubiquitin chains | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.416 |
| SCUBE3 | ANKS1A | ENSP00000274938 | ENSP00000353518 | signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | ankyrin repeat and sterile alpha motif domain containing 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity) | 0.530 |
| SCUBE3 | TCP11 | ENSP00000274938 | ENSP00000308708 | signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | t-complex 11, testis-specific; May play an important role in sperm function and fertility | 0.503 |
| SCUBE3 | ZNF76 | ENSP00000274938 | ENSP00000363064 | signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | zinc finger protein 76; May be involved in transcriptional regulation | 0.529 |
| TCP11 | ANKS1A | ENSP00000308708 | ENSP00000353518 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | ankyrin repeat and sterile alpha motif domain containing 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity) | 0.485 |
| TCP11 | DPEP3 | ENSP00000308708 | ENSP00000268793 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity) | 0.428 |
| TCP11 | FBXW9 | ENSP00000308708 | ENSP00000376945 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | F-box and WD repeat domain containing 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.623 |
| TCP11 | FIG4 | ENSP00000308708 | ENSP00000230124 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes | 0.438 |
| TCP11 | OTUB1 | ENSP00000308708 | ENSP00000402551 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | OTU domain, ubiquitin aldehyde binding 1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes a [...] | 0.416 |
| TCP11 | OTUB2 | ENSP00000308708 | ENSP00000203664 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | OTU domain, ubiquitin aldehyde binding 2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains, with a preference for ’Lys-63’-linked polyubiquitin chains | 0.416 |
| TCP11 | SCUBE3 | ENSP00000308708 | ENSP00000274938 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | 0.503 |
| TCP11 | ZNF143 | ENSP00000308708 | ENSP00000379847 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 | 0.871 |
| TCP11 | ZNF76 | ENSP00000308708 | ENSP00000363064 | t-complex 11, testis-specific; May play an important role in sperm function and fertility | zinc finger protein 76; May be involved in transcriptional regulation | 0.950 |
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