| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHRFAM7A | HTR2A | ENSP00000299847 | ENSP00000367959 | CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | 0.459 |
| CHRFAM7A | RIC3 | ENSP00000299847 | ENSP00000308820 | CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion | resistance to inhibitors of cholinesterase 3 homolog (C. elegans) | 0.607 |
| CHRNA3 | CHRNA4 | ENSP00000315602 | ENSP00000359285 | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 0.904 |
| CHRNA3 | CHRNA7 | ENSP00000315602 | ENSP00000407546 | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | 0.908 |
| CHRNA3 | CHRNB4 | ENSP00000315602 | ENSP00000261751 | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.958 |
| CHRNA3 | RIC3 | ENSP00000315602 | ENSP00000308820 | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | resistance to inhibitors of cholinesterase 3 homolog (C. elegans) | 0.606 |
| CHRNA4 | CHRNA3 | ENSP00000359285 | ENSP00000315602 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.904 |
| CHRNA4 | CHRNA7 | ENSP00000359285 | ENSP00000407546 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | 0.912 |
| CHRNA4 | CHRNB4 | ENSP00000359285 | ENSP00000261751 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.958 |
| CHRNA4 | HTR2A | ENSP00000359285 | ENSP00000367959 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | 0.440 |
| CHRNA4 | HTR7 | ENSP00000359285 | ENSP00000337949 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase | 0.635 |
| CHRNA4 | RIC3 | ENSP00000359285 | ENSP00000308820 | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | resistance to inhibitors of cholinesterase 3 homolog (C. elegans) | 0.928 |
| CHRNA7 | CHRNA3 | ENSP00000407546 | ENSP00000315602 | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.908 |
| CHRNA7 | CHRNA4 | ENSP00000407546 | ENSP00000359285 | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 0.912 |
| CHRNA7 | CHRNB4 | ENSP00000407546 | ENSP00000261751 | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.909 |
| CHRNA7 | HTR2A | ENSP00000407546 | ENSP00000367959 | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | 0.440 |
| CHRNA7 | RIC3 | ENSP00000407546 | ENSP00000308820 | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | resistance to inhibitors of cholinesterase 3 homolog (C. elegans) | 0.606 |
| CHRNB4 | CHRNA3 | ENSP00000261751 | ENSP00000315602 | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.958 |
| CHRNB4 | CHRNA4 | ENSP00000261751 | ENSP00000359285 | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 0.958 |
| CHRNB4 | CHRNA7 | ENSP00000261751 | ENSP00000407546 | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | 0.909 |
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