Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | THAP6 | THAP domain containing 6 (222 aa) | ||||||||||||
Predicted Functional Partners:
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 | N6AMT2 | N-6 adenine-specific DNA methyltransferase 2 (putative); Putative DNA methyltransferase (By similarity) (214 aa) |
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0.789 | ||||||||||
 | THAP10 | THAP domain containing 10 (257 aa) |
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0.649 | ||||||||||
 | RPL7L1 | ribosomal protein L7-like 1 (246 aa) |
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0.579 | ||||||||||
 | LATS1 | LATS, large tumor suppressor, homolog 1 (Drosophila); Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation in [...] (1130 aa) |
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0.549 | ||||||||||
 | PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 (793 aa) |
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0.544 | ||||||||||
 | THAP3 | THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (239 aa) |
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0.538 | ||||||||||
 | HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) (346 aa) |
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0.460 | ||||||||||
 | OR51I2 | olfactory receptor, family 51, subfamily I, member 2; Odorant receptor (Potential) (312 aa) |
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0.416 | ||||||||||
 | ZNF274 | zinc finger protein 274; Probable transcription repressor. Specifically binds to the 3’-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (652 aa) |
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0.414 | ||||||||||
 | PVRIG | poliovirus receptor related immunoglobulin domain containing (326 aa) |
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0.410 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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