node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | B3GNT1 | ENSP00000387356 | ENSP00000309096 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | 0.900 |
ACAN | B3GNT2 | ENSP00000387356 | ENSP00000305595 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | 0.900 |
ACAN | LUM | ENSP00000387356 | ENSP00000266718 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | lumican | 0.996 |
ACAN | OGN | ENSP00000387356 | ENSP00000262551 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.930 |
B3GNT1 | ACAN | ENSP00000309096 | ENSP00000387356 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.900 |
B3GNT1 | B3GNT2 | ENSP00000309096 | ENSP00000305595 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | 0.961 |
B3GNT1 | FUT3 | ENSP00000309096 | ENSP00000305603 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links | 0.902 |
B3GNT1 | FUT4 | ENSP00000309096 | ENSP00000351602 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.906 |
B3GNT1 | FUT5 | ENSP00000309096 | ENSP00000252675 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | fucosyltransferase 5 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens | 0.902 |
B3GNT1 | FUT6 | ENSP00000309096 | ENSP00000286955 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates | 0.902 |
B3GNT1 | FUT9 | ENSP00000309096 | ENSP00000302599 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | fucosyltransferase 9 (alpha (1,3) fucosyltransferase); Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides | 0.902 |
B3GNT1 | GCNT2 | ENSP00000309096 | ENSP00000265012 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C | 0.905 |
B3GNT1 | LUM | ENSP00000309096 | ENSP00000266718 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | lumican | 0.901 |
B3GNT1 | OGN | ENSP00000309096 | ENSP00000262551 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.905 |
B3GNT2 | ACAN | ENSP00000305595 | ENSP00000387356 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.900 |
B3GNT2 | B3GNT1 | ENSP00000305595 | ENSP00000309096 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans | 0.961 |
B3GNT2 | FUT3 | ENSP00000305595 | ENSP00000305603 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links | 0.914 |
B3GNT2 | FUT4 | ENSP00000305595 | ENSP00000351602 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.920 |
B3GNT2 | FUT5 | ENSP00000305595 | ENSP00000252675 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | fucosyltransferase 5 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens | 0.914 |
B3GNT2 | FUT6 | ENSP00000305595 | ENSP00000286955 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates | 0.919 |