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SNRPC SNRPC SHC1 SHC1 ATXN2L ATXN2L RBM24 RBM24 ATXN2 ATXN2 RBFOX1 RBFOX1 CDX1 CDX1 RBPMS RBPMS C1orf94 C1orf94 EPB41 EPB41 ACTG1 ACTG1
"RBFOX1" - RNA binding protein, fox-1 homolog (C. elegans) 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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protein homology
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RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (418 aa)    
Predicted Functional Partners:
ATXN2
ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane (1313 aa)
        score_image   score_image   0.991
RBPMS
RNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA (219 aa)
      score_image score_image   score_image   0.887
SHC1
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
            score_image   0.869
ATXN2L
ataxin 2-like (1097 aa)
            score_image   0.767
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (864 aa)
            score_image   0.680
RBM24
RNA binding motif protein 24; Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3’-UTR of MYOG mRNA and regulates its stability (236 aa)
        score_image   score_image   0.674
C1orf94
chromosome 1 open reading frame 94 (598 aa)
        score_image       0.672
SNRPC
small nuclear ribonucleoprotein polypeptide C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region (159 aa)
            score_image   0.621
ACTG1
actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
            score_image   0.610
CDX1
caudal type homeobox 1; Could play a role in the terminal differentiation of the intestine (265 aa)
            score_image   0.608
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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