Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
DDX54 DDX54 WDR12 WDR12 FKBP6 FKBP6 NIP7 NIP7 NSUN4 NSUN4 NOL6 NOL6 NSUN3 NSUN3 LIMK1 LIMK1 NSUN5 NSUN5 PHLPP2 PHLPP2 PHLPP1 PHLPP1
"NSUN5" - NOP2/Sun domain family, member 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSUN5NOP2/Sun domain family, member 5 (470 aa)    
Predicted Functional Partners:
NSUN4
NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis (384 aa)
    score_image score_image     score_image   0.852
NSUN3
NOP2/Sun domain family, member 3; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (340 aa)
    score_image score_image     score_image   0.768
LIMK1
LIM domain kinase 1 (647 aa)
score_image           score_image   0.759
FKBP6
FK506 binding protein 6, 36kDa (327 aa)
      score_image score_image   score_image   0.705
NIP7
nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa)
score_image     score_image score_image   score_image   0.703
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] (1323 aa)
score_image           score_image   0.687
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] (1717 aa)
score_image           score_image   0.687
DDX54
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa)
      score_image score_image   score_image   0.671
NOL6
nucleolar protein family 6 (RNA-associated) (1146 aa)
      score_image score_image   score_image   0.669
WDR12
WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
      score_image score_image   score_image   0.658
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (35%)