| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSJ | NDST3 | ENSP00000320219 | ENSP00000296499 | arylsulfatase family, member J | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity | 0.444 |
| ARSJ | NDST4 | ENSP00000320219 | ENSP00000264363 | arylsulfatase family, member J | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) | 0.442 |
| ARSJ | TRAM1L1 | ENSP00000320219 | ENSP00000309402 | arylsulfatase family, member J | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.606 |
| HM13 | LMAN1 | ENSP00000381237 | ENSP00000251047 | histocompatibility (minor) 13 | lectin, mannose-binding, 1 | 0.705 |
| HM13 | SSR2 | ENSP00000381237 | ENSP00000295702 | histocompatibility (minor) 13 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.737 |
| HM13 | SSR3 | ENSP00000381237 | ENSP00000265044 | histocompatibility (minor) 13 | signal sequence receptor, gamma (translocon-associated protein gamma); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.736 |
| HM13 | TRAM1L1 | ENSP00000381237 | ENSP00000309402 | histocompatibility (minor) 13 | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.692 |
| KLHL8 | TRAM1L1 | ENSP00000273963 | ENSP00000309402 | kelch-like 8 (Drosophila) | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.730 |
| KLHL8 | UGDH | ENSP00000273963 | ENSP00000319501 | kelch-like 8 (Drosophila) | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.644 |
| LMAN1 | HM13 | ENSP00000251047 | ENSP00000381237 | lectin, mannose-binding, 1 | histocompatibility (minor) 13 | 0.705 |
| LMAN1 | SSR2 | ENSP00000251047 | ENSP00000295702 | lectin, mannose-binding, 1 | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.514 |
| LMAN1 | TRAM1L1 | ENSP00000251047 | ENSP00000309402 | lectin, mannose-binding, 1 | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.580 |
| LMAN1L | SSR2 | ENSP00000310431 | ENSP00000295702 | lectin, mannose-binding, 1 like | signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins | 0.495 |
| LMAN1L | TRAM1L1 | ENSP00000310431 | ENSP00000309402 | lectin, mannose-binding, 1 like | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.573 |
| NDST3 | ARSJ | ENSP00000296499 | ENSP00000320219 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity | arylsulfatase family, member J | 0.444 |
| NDST3 | TRAM1L1 | ENSP00000296499 | ENSP00000309402 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.677 |
| NDST3 | UGDH | ENSP00000296499 | ENSP00000319501 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.592 |
| NDST4 | ARSJ | ENSP00000264363 | ENSP00000320219 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) | arylsulfatase family, member J | 0.442 |
| NDST4 | TRAM1L1 | ENSP00000264363 | ENSP00000309402 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) | translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity) | 0.658 |
| NDST4 | UGDH | ENSP00000264363 | ENSP00000319501 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.587 |
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