node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP2A2 | CLTB | ENSP00000413234 | ENSP00000309415 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.920 |
AP2A2 | CLTC | ENSP00000413234 | ENSP00000269122 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | 0.995 |
AP2A2 | CLTCL1 | ENSP00000413234 | ENSP00000445677 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | clathrin, heavy chain-like 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity) | 0.938 |
AP2A2 | DNAJC6 | ENSP00000413234 | ENSP00000378735 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | 0.697 |
AP2A2 | GAK | ENSP00000413234 | ENSP00000314499 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.451 |
AP2A2 | GGA3 | ENSP00000413234 | ENSP00000245541 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.408 |
AP2A2 | HIP1R | ENSP00000413234 | ENSP00000253083 | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | huntingtin interacting protein 1 related; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis | 0.440 |
ARFGAP1 | ARFGAP3 | ENSP00000314615 | ENSP00000263245 | ADP-ribosylation factor GTPase activating protein 1 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.885 |
ARFGAP1 | CLTB | ENSP00000314615 | ENSP00000309415 | ADP-ribosylation factor GTPase activating protein 1 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.924 |
ARFGAP1 | DNAJC6 | ENSP00000314615 | ENSP00000378735 | ADP-ribosylation factor GTPase activating protein 1 | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | 0.429 |
ARFGAP1 | GGA3 | ENSP00000314615 | ENSP00000245541 | ADP-ribosylation factor GTPase activating protein 1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.930 |
ARFGAP3 | ARFGAP1 | ENSP00000263245 | ENSP00000314615 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | ADP-ribosylation factor GTPase activating protein 1 | 0.885 |
ARFGAP3 | CLTB | ENSP00000263245 | ENSP00000309415 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | 0.916 |
CLTB | AP2A2 | ENSP00000309415 | ENSP00000413234 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | adaptor-related protein complex 2, alpha 2 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as [...] | 0.920 |
CLTB | ARFGAP1 | ENSP00000309415 | ENSP00000314615 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ADP-ribosylation factor GTPase activating protein 1 | 0.924 |
CLTB | ARFGAP3 | ENSP00000309415 | ENSP00000263245 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.916 |
CLTB | CLTC | ENSP00000309415 | ENSP00000269122 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | 0.991 |
CLTB | CLTCL1 | ENSP00000309415 | ENSP00000445677 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | clathrin, heavy chain-like 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity) | 0.948 |
CLTB | DNAJC6 | ENSP00000309415 | ENSP00000378735 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | 0.949 |
CLTB | GAK | ENSP00000309415 | ENSP00000314499 | clathrin, light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.955 |