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IDH3A IDH3A IDH3B IDH3B CS CS ACLY ACLY ALAS2 ALAS2 IDH1 IDH1 UBC UBC ACO1 ACO1 IDH2 IDH2 FBXL5 FBXL5 EPAS1 EPAS1
"ACO1" - aconitase 1, soluble in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ACO1aconitase 1, soluble; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (889 aa)    
Predicted Functional Partners:
CS
citrate synthase (466 aa)
score_image     score_image score_image score_image score_image   0.992
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (452 aa)
score_image     score_image score_image score_image score_image   0.990
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble (414 aa)
score_image     score_image score_image score_image score_image   0.989
UBC
ubiquitin C (685 aa)
        score_image       0.980
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
score_image     score_image   score_image score_image   0.972
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta (385 aa)
score_image     score_image   score_image score_image   0.971
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
score_image     score_image score_image   score_image   0.958
EPAS1
endothelial PAS domain protein 1; Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5’-[AG]CGTG-3’ within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcript [...] (870 aa)
            score_image   0.923
ALAS2
aminolevulinate, delta-, synthase 2 (587 aa)
        score_image   score_image   0.920
FBXL5
F-box and leucine-rich repeat protein 5 (691 aa)
        score_image   score_image   0.915
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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