| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf70 | LAMTOR3 | ENSP00000309561 | ENSP00000424183 | chromosome 19 open reading frame 70 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.644 |
| C19orf70 | MRPL24 | ENSP00000309561 | ENSP00000354525 | chromosome 19 open reading frame 70 | mitochondrial ribosomal protein L24 | 0.644 |
| C19orf70 | RGN | ENSP00000309561 | ENSP00000253303 | chromosome 19 open reading frame 70 | regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity) | 0.472 |
| C19orf70 | SEC16B | ENSP00000309561 | ENSP00000308339 | chromosome 19 open reading frame 70 | SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization | 0.584 |
| C19orf70 | SLC25A3 | ENSP00000309561 | ENSP00000228318 | chromosome 19 open reading frame 70 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | 0.644 |
| C19orf70 | UBC | ENSP00000309561 | ENSP00000344818 | chromosome 19 open reading frame 70 | ubiquitin C | 0.483 |
| LAMTOR3 | C19orf70 | ENSP00000424183 | ENSP00000309561 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | chromosome 19 open reading frame 70 | 0.644 |
| LAMTOR3 | UBC | ENSP00000424183 | ENSP00000344818 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | ubiquitin C | 0.483 |
| MRPL24 | C19orf70 | ENSP00000354525 | ENSP00000309561 | mitochondrial ribosomal protein L24 | chromosome 19 open reading frame 70 | 0.644 |
| MRPL24 | UBC | ENSP00000354525 | ENSP00000344818 | mitochondrial ribosomal protein L24 | ubiquitin C | 0.553 |
| RGN | C19orf70 | ENSP00000253303 | ENSP00000309561 | regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity) | chromosome 19 open reading frame 70 | 0.472 |
| RGN | SEC16B | ENSP00000253303 | ENSP00000308339 | regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity) | SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization | 0.860 |
| SEC16B | C19orf70 | ENSP00000308339 | ENSP00000309561 | SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization | chromosome 19 open reading frame 70 | 0.584 |
| SEC16B | RGN | ENSP00000308339 | ENSP00000253303 | SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization | regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity) | 0.860 |
| SLC25A3 | C19orf70 | ENSP00000228318 | ENSP00000309561 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | chromosome 19 open reading frame 70 | 0.644 |
| SLC25A3 | UBC | ENSP00000228318 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | ubiquitin C | 0.976 |
| UBC | C19orf70 | ENSP00000344818 | ENSP00000309561 | ubiquitin C | chromosome 19 open reading frame 70 | 0.483 |
| UBC | LAMTOR3 | ENSP00000344818 | ENSP00000424183 | ubiquitin C | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.483 |
| UBC | MRPL24 | ENSP00000344818 | ENSP00000354525 | ubiquitin C | mitochondrial ribosomal protein L24 | 0.553 |
| UBC | SLC25A3 | ENSP00000344818 | ENSP00000228318 | ubiquitin C | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | 0.976 |
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