Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SLC25A37 SLC25A37 ATP9B ATP9B TMEM5 TMEM5 TMEM254 TMEM254 MFF MFF BOD1 BOD1 CACNA1B CACNA1B UBC UBC SLC25A28 SLC25A28 AAGAB AAGAB TNKS2 TNKS2
"BOD1" - biorientation of chromosomes in cell division 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BOD1biorientation of chromosomes in cell division 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (185 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.721
ATP9B
ATPase, class II, type 9B (1147 aa)
            score_image   0.609
TMEM5
transmembrane protein 5 (443 aa)
            score_image   0.588
TMEM254
transmembrane protein 254 (123 aa)
            score_image   0.583
MFF
mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission (342 aa)
            score_image   0.580
AAGAB
alpha- and gamma-adaptin binding protein; May be involved in endocytic recycling of growth factor receptors such as EGFR (315 aa)
            score_image   0.539
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subseque [...] (1166 aa)
            score_image   0.509
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (338 aa)
            score_image   0.485
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (364 aa)
            score_image   0.485
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] (2340 aa)
            score_image   0.437
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (53%)