CA5A protein (Homo sapiens) - STRING network view

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CA5A

carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity (305 aa)

Predicted Functional Partners:

CYP24A1

0.730

SLC25A19

0.646

UHMK1

0.565

GGT5

0.525

CDC37

0.514

PM20D2

0.504

ENPP4

0.493

ENPP5

0.478

AANAT

0.477

CRISPLD2

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AANAT	CA5A	ENSP00000250615	ENSP00000309649	aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	0.477
AANAT	ENPP4	ENSP00000250615	ENSP00000318066	aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	0.539
CA5A	AANAT	ENSP00000309649	ENSP00000250615	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin	0.477
CA5A	CDC37	ENSP00000309649	ENSP00000222005	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity	0.514
CA5A	CRISPLD2	ENSP00000309649	ENSP00000262424	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity)	0.459
CA5A	CYP24A1	ENSP00000309649	ENSP00000216862	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	cytochrome P450, family 24, subfamily A, polypeptide 1; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product	0.730
CA5A	ENPP4	ENSP00000309649	ENSP00000318066	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	0.493
CA5A	ENPP5	ENSP00000309649	ENSP00000230565	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative); May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity)	0.478
CA5A	GGT5	ENSP00000309649	ENSP00000381340	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)	0.525
CA5A	PM20D2	ENSP00000309649	ENSP00000275072	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	peptidase M20 domain containing 2	0.504
CA5A	SLC25A19	ENSP00000309649	ENSP00000319574	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria	0.646
CA5A	UHMK1	ENSP00000309649	ENSP00000420270	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	U2AF homology motif (UHM) kinase 1; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)	0.565
CDC37	CA5A	ENSP00000222005	ENSP00000309649	cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	0.514
CRISPLD2	CA5A	ENSP00000262424	ENSP00000309649	cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity)	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	0.459
CRISPLD2	ENPP4	ENSP00000262424	ENSP00000318066	cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity)	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	0.482
CRISPLD2	PM20D2	ENSP00000262424	ENSP00000275072	cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity)	peptidase M20 domain containing 2	0.475
CYP24A1	CA5A	ENSP00000216862	ENSP00000309649	cytochrome P450, family 24, subfamily A, polypeptide 1; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	0.730
ENPP4	AANAT	ENSP00000318066	ENSP00000250615	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin	0.539
ENPP4	CA5A	ENSP00000318066	ENSP00000309649	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	carbonic anhydrase VA, mitochondrial; Reversible hydration of carbon dioxide. Low activity	0.493
ENPP4	CRISPLD2	ENSP00000318066	ENSP00000262424	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors	cysteine-rich secretory protein LCCL domain containing 2; Promotes matrix assembly (By similarity)	0.482

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