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STRINGSTRING
FGD5 FGD5 TOPAZ1 TOPAZ1 POTEI POTEI POTEE POTEE LRRN4 LRRN4 CACNB2 CACNB2 LRCH4 LRCH4 LRRC3 LRRC3 RBBP6 RBBP6 BCAS3 BCAS3 PLLP PLLP
"LRCH4" - leucine-rich repeats and calponin homology in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRCH4leucine-rich repeats and calponin homology (CH) domain containing 4 (683 aa)    
Predicted Functional Partners:
TOPAZ1
testis and ovary specific PAZ domain containing 1 (1692 aa)
            score_image   0.586
RBBP6
retinoblastoma binding protein 6 (1792 aa)
        score_image       0.571
LRRN4
leucine rich repeat neuronal 4; May play an important role in hippocampus-dependent long-lasting memory (By similarity) (740 aa)
            score_image   0.559
LRRC3
leucine rich repeat containing 3 (257 aa)
            score_image   0.559
PLLP
plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity) (182 aa)
            score_image   0.545
BCAS3
breast carcinoma amplified sequence 3 (928 aa)
            score_image   0.544
CACNB2
calcium channel, voltage-dependent, beta 2 subunit (660 aa)
            score_image   0.542
FGD5
FYVE, RhoGEF and PH domain containing 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (1462 aa)
            score_image   0.534
POTEE
POTE ankyrin domain family member E (1075 aa)
        score_image   score_image   0.526
POTEI
POTE ankyrin domain family, member I (1075 aa)
        score_image   score_image   0.526
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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