node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A1CF | APOBEC3D | ENSP00000282641 | ENSP00000216099 | APOBEC1 complementation factor | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | 0.731 |
A1CF | APOBEC3F | ENSP00000282641 | ENSP00000309749 | APOBEC1 complementation factor | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | 0.720 |
A1CF | APOBEC3G | ENSP00000282641 | ENSP00000385057 | APOBEC1 complementation factor | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral [...] | 0.811 |
A1CF | CDA | ENSP00000282641 | ENSP00000364212 | APOBEC1 complementation factor | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.509 |
APOBEC3D | A1CF | ENSP00000216099 | ENSP00000282641 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | APOBEC1 complementation factor | 0.731 |
APOBEC3D | APOBEC3F | ENSP00000216099 | ENSP00000309749 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | 0.722 |
APOBEC3D | APOBEC3G | ENSP00000216099 | ENSP00000385057 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral [...] | 0.744 |
APOBEC3D | APOBEC4 | ENSP00000216099 | ENSP00000310622 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); Putative C to U editing enzyme whose physiological substrate is not yet known (By similarity) | 0.779 |
APOBEC3D | CDA | ENSP00000216099 | ENSP00000364212 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.687 |
APOBEC3D | DND1 | ENSP00000216099 | ENSP00000445366 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | dead end homolog 1 (zebrafish); RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3’ untranslated region (3’-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration ( [...] | 0.639 |
APOBEC3D | SAMHD1 | ENSP00000216099 | ENSP00000262878 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | SAM domain and HD domain 1; Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling | 0.577 |
APOBEC3D | TCEB1 | ENSP00000216099 | ENSP00000284811 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.547 |
APOBEC3F | A1CF | ENSP00000309749 | ENSP00000282641 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | APOBEC1 complementation factor | 0.720 |
APOBEC3F | APOBEC3D | ENSP00000309749 | ENSP00000216099 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | 0.722 |
APOBEC3F | APOBEC3G | ENSP00000309749 | ENSP00000385057 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral [...] | 0.880 |
APOBEC3F | APOBEC4 | ENSP00000309749 | ENSP00000310622 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); Putative C to U editing enzyme whose physiological substrate is not yet known (By similarity) | 0.582 |
APOBEC3F | CDA | ENSP00000309749 | ENSP00000364212 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.481 |
APOBEC3F | DND1 | ENSP00000309749 | ENSP00000445366 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | dead end homolog 1 (zebrafish); RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3’ untranslated region (3’-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration ( [...] | 0.639 |
APOBEC3F | SAMHD1 | ENSP00000309749 | ENSP00000262878 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | SAM domain and HD domain 1; Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling | 0.485 |
APOBEC3F | TBC1D26 | ENSP00000309749 | ENSP00000410111 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] | TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) | 0.473 |