| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AVEN | GPR83 | ENSP00000306822 | ENSP00000243673 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | 0.875 |
| AVEN | MEST | ENSP00000306822 | ENSP00000223215 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | mesoderm specific transcript homolog (mouse) | 0.870 |
| AVEN | NLRP6 | ENSP00000306822 | ENSP00000309767 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.502 |
| AVEN | SELV | ENSP00000306822 | ENSP00000333956 | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | selenoprotein V ; May be involved in a redox-related process (Potential) | 0.909 |
| CXXC5 | NLRP6 | ENSP00000302543 | ENSP00000309767 | CXXC finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.499 |
| GPR83 | AVEN | ENSP00000243673 | ENSP00000306822 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | 0.875 |
| GPR83 | MEST | ENSP00000243673 | ENSP00000223215 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | mesoderm specific transcript homolog (mouse) | 0.885 |
| GPR83 | NLRP6 | ENSP00000243673 | ENSP00000309767 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.540 |
| GPR83 | SELV | ENSP00000243673 | ENSP00000333956 | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | selenoprotein V ; May be involved in a redox-related process (Potential) | 0.909 |
| HRC | NLRP6 | ENSP00000252825 | ENSP00000309767 | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.590 |
| MEFV | NLRP6 | ENSP00000219596 | ENSP00000309767 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.609 |
| MEFV | PYCARD | ENSP00000219596 | ENSP00000247470 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | PYD and CARD domain containing; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory [...] | 0.989 |
| MEST | AVEN | ENSP00000223215 | ENSP00000306822 | mesoderm specific transcript homolog (mouse) | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | 0.870 |
| MEST | GPR83 | ENSP00000223215 | ENSP00000243673 | mesoderm specific transcript homolog (mouse) | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | 0.885 |
| MEST | NLRP6 | ENSP00000223215 | ENSP00000309767 | mesoderm specific transcript homolog (mouse) | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | 0.520 |
| MEST | SELV | ENSP00000223215 | ENSP00000333956 | mesoderm specific transcript homolog (mouse) | selenoprotein V ; May be involved in a redox-related process (Potential) | 0.906 |
| NLRP6 | AVEN | ENSP00000309767 | ENSP00000306822 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 | 0.502 |
| NLRP6 | CXXC5 | ENSP00000309767 | ENSP00000302543 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | CXXC finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis | 0.499 |
| NLRP6 | GPR83 | ENSP00000309767 | ENSP00000243673 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | G protein-coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor | 0.540 |
| NLRP6 | HRC | ENSP00000309767 | ENSP00000252825 | NLR family, pyrin domain containing 6; May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, i [...] | histidine rich calcium binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle | 0.590 |
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