| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREB3L1 | TMEM234 | ENSP00000434939 | ENSP00000309792 | cAMP responsive element binding protein 3-like 1; Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity) | transmembrane protein 234 | 0.483 |
| FCHO2 | TMEM234 | ENSP00000393776 | ENSP00000309792 | FCH domain only 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocyto [...] | transmembrane protein 234 | 0.646 |
| NIPAL1 | SLC35B3 | ENSP00000295461 | ENSP00000368981 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | 0.692 |
| NIPAL1 | SLC35C1 | ENSP00000295461 | ENSP00000313318 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | 0.545 |
| NIPAL1 | SLC35C2 | ENSP00000295461 | ENSP00000243896 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | solute carrier family 35, member C2; May play an important role in the cellular response to tissue hypoxia | 0.690 |
| NIPAL1 | SLC35F1 | ENSP00000295461 | ENSP00000353557 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | solute carrier family 35, member F1; Putative solute transporter (Potential) | 0.683 |
| NIPAL1 | SLC39A11 | ENSP00000295461 | ENSP00000445829 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | solute carrier family 39 (metal ion transporter), member 11; May act as a zinc-influx transporter (By similarity) | 0.432 |
| NIPAL1 | TMEM234 | ENSP00000295461 | ENSP00000309792 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | transmembrane protein 234 | 0.502 |
| POLR2C | TMEM234 | ENSP00000219252 | ENSP00000309792 | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity) | transmembrane protein 234 | 0.483 |
| SLC35B3 | NIPAL1 | ENSP00000368981 | ENSP00000295461 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | 0.692 |
| SLC35B3 | SLC35C1 | ENSP00000368981 | ENSP00000313318 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | 0.765 |
| SLC35B3 | SLC35C2 | ENSP00000368981 | ENSP00000243896 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | solute carrier family 35, member C2; May play an important role in the cellular response to tissue hypoxia | 0.672 |
| SLC35B3 | SLC35F1 | ENSP00000368981 | ENSP00000353557 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | solute carrier family 35, member F1; Putative solute transporter (Potential) | 0.668 |
| SLC35B3 | SLC35F2 | ENSP00000368981 | ENSP00000393571 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | solute carrier family 35, member F2; Putative solute transporter (Potential) | 0.563 |
| SLC35B3 | SLC39A11 | ENSP00000368981 | ENSP00000445829 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | solute carrier family 39 (metal ion transporter), member 11; May act as a zinc-influx transporter (By similarity) | 0.536 |
| SLC35B3 | TMEM234 | ENSP00000368981 | ENSP00000309792 | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | transmembrane protein 234 | 0.657 |
| SLC35C1 | NIPAL1 | ENSP00000313318 | ENSP00000295461 | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | 0.545 |
| SLC35C1 | SLC35B3 | ENSP00000313318 | ENSP00000368981 | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon | 0.765 |
| SLC35C1 | SLC35C2 | ENSP00000313318 | ENSP00000243896 | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | solute carrier family 35, member C2; May play an important role in the cellular response to tissue hypoxia | 0.835 |
| SLC35C1 | SLC35F1 | ENSP00000313318 | ENSP00000353557 | solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen | solute carrier family 35, member F1; Putative solute transporter (Potential) | 0.584 |
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