node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGEF1 | ARFGEF2 | ENSP00000262215 | ENSP00000360985 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | 0.810 |
ARFGEF1 | PRICKLE2 | ENSP00000262215 | ENSP00000295902 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | prickle homolog 2 (Drosophila) | 0.402 |
ARFGEF1 | RSBN1 | ENSP00000262215 | ENSP00000261441 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | round spermatid basic protein 1 | 0.483 |
ARFGEF1 | TBC1D16 | ENSP00000262215 | ENSP00000309794 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | TBC1 domain family, member 16; May act as a GTPase-activating protein for Rab family protein(s) | 0.476 |
ARFGEF1 | USP32 | ENSP00000262215 | ENSP00000300896 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | ubiquitin specific peptidase 32 | 0.402 |
ARFGEF2 | ARFGEF1 | ENSP00000360985 | ENSP00000262215 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate [...] | 0.810 |
ARFGEF2 | BCAS4 | ENSP00000360985 | ENSP00000351642 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | breast carcinoma amplified sequence 4 | 0.417 |
ARFGEF2 | DEPDC1B | ENSP00000360985 | ENSP00000265036 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | DEP domain containing 1B | 0.504 |
ARFGEF2 | PRICKLE2 | ENSP00000360985 | ENSP00000295902 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | prickle homolog 2 (Drosophila) | 0.464 |
ARFGEF2 | RSBN1 | ENSP00000360985 | ENSP00000261441 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | round spermatid basic protein 1 | 0.534 |
ARFGEF2 | TBC1D16 | ENSP00000360985 | ENSP00000309794 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | TBC1 domain family, member 16; May act as a GTPase-activating protein for Rab family protein(s) | 0.509 |
ARFGEF2 | USP32 | ENSP00000360985 | ENSP00000300896 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | ubiquitin specific peptidase 32 | 0.433 |
BCAS4 | ARFGEF2 | ENSP00000351642 | ENSP00000360985 | breast carcinoma amplified sequence 4 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | 0.417 |
BCAS4 | DEPDC1B | ENSP00000351642 | ENSP00000265036 | breast carcinoma amplified sequence 4 | DEP domain containing 1B | 0.464 |
BCAS4 | PRICKLE2 | ENSP00000351642 | ENSP00000295902 | breast carcinoma amplified sequence 4 | prickle homolog 2 (Drosophila) | 0.449 |
BCAS4 | RSBN1 | ENSP00000351642 | ENSP00000261441 | breast carcinoma amplified sequence 4 | round spermatid basic protein 1 | 0.495 |
BCAS4 | TBC1D16 | ENSP00000351642 | ENSP00000309794 | breast carcinoma amplified sequence 4 | TBC1 domain family, member 16; May act as a GTPase-activating protein for Rab family protein(s) | 0.464 |
BCAS4 | USP32 | ENSP00000351642 | ENSP00000300896 | breast carcinoma amplified sequence 4 | ubiquitin specific peptidase 32 | 0.533 |
DEPDC1B | ARFGEF2 | ENSP00000265036 | ENSP00000360985 | DEP domain containing 1B | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling [...] | 0.504 |
DEPDC1B | BCAS4 | ENSP00000265036 | ENSP00000351642 | DEP domain containing 1B | breast carcinoma amplified sequence 4 | 0.464 |