node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRAF | EGFR | ENSP00000288602 | ENSP00000275493 | v-raf murine sarcoma viral oncogene homolog B1 | epidermal growth factor receptor | 0.541 |
BRAF | HRAS | ENSP00000288602 | ENSP00000309845 | v-raf murine sarcoma viral oncogene homolog B1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.999 |
BRAF | PIK3CA | ENSP00000288602 | ENSP00000263967 | v-raf murine sarcoma viral oncogene homolog B1 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to variou [...] | 0.684 |
BRAF | RAF1 | ENSP00000288602 | ENSP00000251849 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.999 |
BRAF | SOS1 | ENSP00000288602 | ENSP00000384675 | v-raf murine sarcoma viral oncogene homolog B1 | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.714 |
BRAF | SRC | ENSP00000288602 | ENSP00000350941 | v-raf murine sarcoma viral oncogene homolog B1 | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.513 |
EGFR | BRAF | ENSP00000275493 | ENSP00000288602 | epidermal growth factor receptor | v-raf murine sarcoma viral oncogene homolog B1 | 0.541 |
EGFR | HRAS | ENSP00000275493 | ENSP00000309845 | epidermal growth factor receptor | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.999 |
EGFR | PIK3CA | ENSP00000275493 | ENSP00000263967 | epidermal growth factor receptor | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to variou [...] | 0.988 |
EGFR | RAF1 | ENSP00000275493 | ENSP00000251849 | epidermal growth factor receptor | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.740 |
EGFR | RALGDS | ENSP00000275493 | ENSP00000361120 | epidermal growth factor receptor | ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap | 0.428 |
EGFR | RASA1 | ENSP00000275493 | ENSP00000274376 | epidermal growth factor receptor | RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 | 0.996 |
EGFR | RIN1 | ENSP00000275493 | ENSP00000310406 | epidermal growth factor receptor | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis | 0.929 |
EGFR | SOS1 | ENSP00000275493 | ENSP00000384675 | epidermal growth factor receptor | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.999 |
EGFR | SRC | ENSP00000275493 | ENSP00000350941 | epidermal growth factor receptor | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.999 |
HRAS | BRAF | ENSP00000309845 | ENSP00000288602 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-raf murine sarcoma viral oncogene homolog B1 | 0.999 |
HRAS | EGFR | ENSP00000309845 | ENSP00000275493 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | epidermal growth factor receptor | 0.999 |
HRAS | PIK3CA | ENSP00000309845 | ENSP00000263967 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to variou [...] | 0.999 |
HRAS | RAF1 | ENSP00000309845 | ENSP00000251849 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.999 |
HRAS | RALGDS | ENSP00000309845 | ENSP00000361120 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap | 0.999 |