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MFAP4 MFAP4 FBLN2 FBLN2 EFEMP1 EFEMP1 MFAP5 MFAP5 EFEMP2 EFEMP2 MFAP1 MFAP1 FBLN1 FBLN1 MFAP2 MFAP2 MFAP3 MFAP3 FBLN5 FBLN5 LOX LOX
"EFEMP2" - EGF containing fibulin-like extracellular matrix protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
EFEMP2EGF containing fibulin-like extracellular matrix protein 2 (443 aa)    
Predicted Functional Partners:
LOX
lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression (417 aa)
        score_image   score_image   0.989
FBLN5
fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling (448 aa)
        score_image score_image score_image score_image 0.957
MFAP2
microfibrillar-associated protein 2; Component of the elastin-associated microfibrils (183 aa)
          score_image score_image   0.936
MFAP5
microfibrillar associated protein 5; Component of the elastin-associated microfibrils (173 aa)
          score_image score_image   0.931
MFAP1
microfibrillar-associated protein 1; Component of the elastin-associated microfibrils (439 aa)
          score_image score_image   0.920
FBLN1
fibulin 1 (703 aa)
          score_image score_image score_image 0.911
FBLN2
fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent (1231 aa)
      score_image   score_image score_image score_image 0.909
MFAP4
microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions (279 aa)
          score_image score_image   0.905
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (493 aa)
          score_image score_image score_image 0.902
MFAP3
microfibrillar-associated protein 3; Component of the elastin-associated microfibrils (362 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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