node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFEMP1 | EFEMP2 | ENSP00000347596 | ENSP00000309953 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | EGF containing fibulin-like extracellular matrix protein 2 | 0.902 |
EFEMP1 | FBLN1 | ENSP00000347596 | ENSP00000331544 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 1 | 0.914 |
EFEMP1 | FBLN2 | ENSP00000347596 | ENSP00000384169 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.910 |
EFEMP1 | FBLN5 | ENSP00000347596 | ENSP00000345008 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.904 |
EFEMP1 | MFAP1 | ENSP00000347596 | ENSP00000267812 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.921 |
EFEMP1 | MFAP2 | ENSP00000347596 | ENSP00000364685 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.927 |
EFEMP1 | MFAP3 | ENSP00000347596 | ENSP00000322956 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 3; Component of the elastin-associated microfibrils | 0.900 |
EFEMP1 | MFAP4 | ENSP00000347596 | ENSP00000378957 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions | 0.905 |
EFEMP1 | MFAP5 | ENSP00000347596 | ENSP00000352455 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.922 |
EFEMP2 | EFEMP1 | ENSP00000309953 | ENSP00000347596 | EGF containing fibulin-like extracellular matrix protein 2 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | 0.902 |
EFEMP2 | FBLN1 | ENSP00000309953 | ENSP00000331544 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 1 | 0.911 |
EFEMP2 | FBLN2 | ENSP00000309953 | ENSP00000384169 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.909 |
EFEMP2 | FBLN5 | ENSP00000309953 | ENSP00000345008 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.957 |
EFEMP2 | LOX | ENSP00000309953 | ENSP00000231004 | EGF containing fibulin-like extracellular matrix protein 2 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.989 |
EFEMP2 | MFAP1 | ENSP00000309953 | ENSP00000267812 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.920 |
EFEMP2 | MFAP2 | ENSP00000309953 | ENSP00000364685 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.936 |
EFEMP2 | MFAP3 | ENSP00000309953 | ENSP00000322956 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 3; Component of the elastin-associated microfibrils | 0.900 |
EFEMP2 | MFAP4 | ENSP00000309953 | ENSP00000378957 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions | 0.905 |
EFEMP2 | MFAP5 | ENSP00000309953 | ENSP00000352455 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.931 |
FBLN1 | EFEMP1 | ENSP00000331544 | ENSP00000347596 | fibulin 1 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | 0.914 |