node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNTL | ESR2 | ENSP00000374357 | ENSP00000343925 | aryl hydrocarbon receptor nuclear translocator-like | estrogen receptor 2 (ER beta) | 0.450 |
ARNTL | NCOR1 | ENSP00000374357 | ENSP00000268712 | aryl hydrocarbon receptor nuclear translocator-like | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.948 |
ARNTL | NR1D1 | ENSP00000374357 | ENSP00000246672 | aryl hydrocarbon receptor nuclear translocator-like | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.994 |
ARNTL | NR1D2 | ENSP00000374357 | ENSP00000310006 | aryl hydrocarbon receptor nuclear translocator-like | nuclear receptor subfamily 1, group D, member 2; Binds to the sequences 5’-AATGTAGGTCA-3’ and 5’- ATAACTAGGTCA-3’. Acts as a potent competitive repressor of ROR alpha function (By similarity) | 0.948 |
ARNTL | RORA | ENSP00000374357 | ENSP00000261523 | aryl hydrocarbon receptor nuclear translocator-like | RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5’-[AT][TA]A[AT][CGT]TAGGTCA-3’. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] | 0.973 |
ARNTL | RORB | ENSP00000374357 | ENSP00000366093 | aryl hydrocarbon receptor nuclear translocator-like | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.751 |
ARNTL | RORC | ENSP00000374357 | ENSP00000327025 | aryl hydrocarbon receptor nuclear translocator-like | RAR-related orphan receptor C; Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock | 0.743 |
ESR2 | ARNTL | ENSP00000343925 | ENSP00000374357 | estrogen receptor 2 (ER beta) | aryl hydrocarbon receptor nuclear translocator-like | 0.450 |
ESR2 | NCOR1 | ENSP00000343925 | ENSP00000268712 | estrogen receptor 2 (ER beta) | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.956 |
ESR2 | NR0B2 | ENSP00000343925 | ENSP00000254227 | estrogen receptor 2 (ER beta) | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.968 |
ESR2 | NR1D1 | ENSP00000343925 | ENSP00000246672 | estrogen receptor 2 (ER beta) | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.917 |
ESR2 | NR1D2 | ENSP00000343925 | ENSP00000310006 | estrogen receptor 2 (ER beta) | nuclear receptor subfamily 1, group D, member 2; Binds to the sequences 5’-AATGTAGGTCA-3’ and 5’- ATAACTAGGTCA-3’. Acts as a potent competitive repressor of ROR alpha function (By similarity) | 0.912 |
ESR2 | NR4A1 | ENSP00000343925 | ENSP00000353427 | estrogen receptor 2 (ER beta) | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.916 |
ESR2 | RORA | ENSP00000343925 | ENSP00000261523 | estrogen receptor 2 (ER beta) | RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5’-[AT][TA]A[AT][CGT]TAGGTCA-3’. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] | 0.914 |
ESR2 | RORB | ENSP00000343925 | ENSP00000366093 | estrogen receptor 2 (ER beta) | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.914 |
ESR2 | RORC | ENSP00000343925 | ENSP00000327025 | estrogen receptor 2 (ER beta) | RAR-related orphan receptor C; Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock | 0.913 |
NCOR1 | ARNTL | ENSP00000268712 | ENSP00000374357 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | aryl hydrocarbon receptor nuclear translocator-like | 0.948 |
NCOR1 | ESR2 | ENSP00000268712 | ENSP00000343925 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | estrogen receptor 2 (ER beta) | 0.956 |
NCOR1 | NR0B2 | ENSP00000268712 | ENSP00000254227 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.454 |
NCOR1 | NR1D1 | ENSP00000268712 | ENSP00000246672 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.994 |