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RORC RORC RORB RORB NR4A1 NR4A1 ESR2 ESR2 NR0B2 NR0B2 RORA RORA NR1D1 NR1D1 NR1D2 NR1D2 NCOR1 NCOR1 ARNTL ARNTL SKP1 SKP1
"NR1D2" - nuclear receptor subfamily 1, group D, member 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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NR1D2nuclear receptor subfamily 1, group D, member 2; Binds to the sequences 5’-AATGTAGGTCA-3’ and 5’- ATAACTAGGTCA-3’. Acts as a potent competitive repressor of ROR alpha function (By similarity) (579 aa)    
Predicted Functional Partners:
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
        score_image       0.999
NCOR1
nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors (2440 aa)
        score_image   score_image   0.985
RORC
RAR-related orphan receptor C; Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock (518 aa)
      score_image score_image score_image score_image score_image 0.952
ARNTL
aryl hydrocarbon receptor nuclear translocator-like (625 aa)
            score_image   0.948
NR1D1
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine (614 aa)
      score_image score_image score_image score_image score_image 0.940
RORA
RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5’-[AT][TA]A[AT][CGT]TAGGTCA-3’. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] (556 aa)
      score_image   score_image score_image score_image 0.929
RORB
RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) (459 aa)
      score_image   score_image score_image score_image 0.928
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 (257 aa)
          score_image score_image   0.920
ESR2
estrogen receptor 2 (ER beta) (530 aa)
          score_image score_image score_image 0.912
NR4A1
nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 (611 aa)
          score_image score_image score_image 0.911
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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