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STRINGSTRING
MAP3K5 MAP3K5 MELK MELK MYBL2 MYBL2 DNAJC21 DNAJC21 ZNF622 ZNF622 ENSG00000257411 ENSG00000257411 PA2G4 PA2G4 EIF6 EIF6 NMD3 NMD3 LSG1 LSG1 RSL24D1 RSL24D1
"ZNF622" - zinc finger protein 622 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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ZNF622zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development (477 aa)    
Predicted Functional Partners:
MELK
maternal embryonic leucine zipper kinase (651 aa)
         score_image   score_image   0.990
MYBL2
v-myb myeloblastosis viral oncogene homolog (avian)-like 2; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (700 aa)
       score_image score_image   score_image   0.980
NMD3
NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit (503 aa)
       score_image score_image   score_image   0.943
DNAJC21
DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70 (576 aa)
       score_image score_image   score_image   0.935
MAP3K5
mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] (1374 aa)
         score_image   score_image   0.925
LSG1
large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) (658 aa)
       score_image score_image   score_image   0.924
EIF6
eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa)
       score_image score_image   score_image   0.886
ENSG00000257411
Uncharacterized protein (163 aa)
       score_image score_image   score_image   0.823
PA2G4
proliferation-associated 2G4, 38kDa; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in [...] (394 aa)
       score_image score_image   score_image   0.823
RSL24D1
ribosomal L24 domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity) (163 aa)
       score_image score_image   score_image   0.763
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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