| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRYAA | HSP90AA1 | ENSP00000291554 | ENSP00000335153 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.467 |
| CRYAA | HSPB7 | ENSP00000291554 | ENSP00000310111 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.472 |
| CRYAA | HSPB9 | ENSP00000291554 | ENSP00000347178 | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | heat shock protein, alpha-crystallin-related, B9 | 0.531 |
| EIF2B1 | HSPB3 | ENSP00000416250 | ENSP00000303394 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.485 |
| EIF2B1 | HSPB7 | ENSP00000416250 | ENSP00000310111 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.485 |
| FLNA | HSPB7 | ENSP00000358866 | ENSP00000310111 | filamin A, alpha; Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.680 |
| FRMD4B | HSPB7 | ENSP00000381549 | ENSP00000310111 | FERM domain containing 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity) | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.512 |
| HSP90AA1 | CRYAA | ENSP00000335153 | ENSP00000291554 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions | 0.467 |
| HSP90AA1 | HSPA13 | ENSP00000335153 | ENSP00000285667 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | 0.957 |
| HSP90AA1 | HSPB3 | ENSP00000335153 | ENSP00000303394 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.884 |
| HSP90AA1 | HSPB7 | ENSP00000335153 | ENSP00000310111 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.511 |
| HSP90AA1 | HSPB8 | ENSP00000335153 | ENSP00000281938 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.657 |
| HSP90AA1 | HSPB9 | ENSP00000335153 | ENSP00000347178 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein, alpha-crystallin-related, B9 | 0.429 |
| HSPA13 | HSP90AA1 | ENSP00000285667 | ENSP00000335153 | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.957 |
| HSPA13 | HSPB7 | ENSP00000285667 | ENSP00000310111 | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.531 |
| HSPB3 | EIF2B1 | ENSP00000303394 | ENSP00000416250 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP | 0.485 |
| HSPB3 | HSP90AA1 | ENSP00000303394 | ENSP00000335153 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.884 |
| HSPB3 | HSPB7 | ENSP00000303394 | ENSP00000310111 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | heat shock 27kDa protein family, member 7 (cardiovascular) | 0.845 |
| HSPB3 | HSPB8 | ENSP00000303394 | ENSP00000281938 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | heat shock 22kDa protein 8; Displays temperature-dependent chaperone activity | 0.682 |
| HSPB3 | HSPB9 | ENSP00000303394 | ENSP00000347178 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | heat shock protein, alpha-crystallin-related, B9 | 0.623 |
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