| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC16 | PPP3CB | ENSP00000348554 | ENSP00000378306 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | 0.842 |
| CDC16 | PPP3R2 | ENSP00000348554 | ENSP00000363939 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | 0.800 |
| CDC16 | TBC1D10C | ENSP00000348554 | ENSP00000310193 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.421 |
| CDC16 | TBC1D21 | ENSP00000348554 | ENSP00000300504 | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | 0.646 |
| DIS3 | TBC1D10C | ENSP00000366997 | ENSP00000310193 | DIS3 mitotic control homolog (S. cerevisiae) | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.495 |
| ENSG00000260272 | TBC1D10C | ENSP00000455547 | ENSP00000310193 | Uncharacterized protein | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.501 |
| ENSG00000260272 | TBC1D21 | ENSP00000455547 | ENSP00000300504 | Uncharacterized protein | TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) | 0.472 |
| EPGN | TBC1D10C | ENSP00000330375 | ENSP00000310193 | epithelial mitogen homolog (mouse); Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.410 |
| PPP3CB | CDC16 | ENSP00000378306 | ENSP00000348554 | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.842 |
| PPP3CB | PPP3R2 | ENSP00000378306 | ENSP00000363939 | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | 0.886 |
| PPP3CB | TBC1D10C | ENSP00000378306 | ENSP00000310193 | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.604 |
| PPP3R2 | CDC16 | ENSP00000363939 | ENSP00000348554 | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.800 |
| PPP3R2 | PPP3CB | ENSP00000363939 | ENSP00000378306 | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | 0.886 |
| PPP3R2 | TBC1D10C | ENSP00000363939 | ENSP00000310193 | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.576 |
| RAB35 | TBC1D10C | ENSP00000229340 | ENSP00000310193 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | 0.552 |
| TBC1D10C | CDC16 | ENSP00000310193 | ENSP00000348554 | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | cell division cycle 16 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains | 0.421 |
| TBC1D10C | DIS3 | ENSP00000310193 | ENSP00000366997 | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | DIS3 mitotic control homolog (S. cerevisiae) | 0.495 |
| TBC1D10C | ENSG00000260272 | ENSP00000310193 | ENSP00000455547 | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | Uncharacterized protein | 0.501 |
| TBC1D10C | EPGN | ENSP00000310193 | ENSP00000330375 | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | epithelial mitogen homolog (mouse); Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases | 0.410 |
| TBC1D10C | PPP3CB | ENSP00000310193 | ENSP00000378306 | TBC1 domain family, member 10C; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras | protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | 0.604 |
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