node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABLIM1 | ABLIM2 | ENSP00000338190 | ENSP00000393511 | actin binding LIM protein 1 | actin binding LIM protein family, member 2 | 0.904 |
ABLIM1 | ABLIM3 | ENSP00000338190 | ENSP00000310309 | actin binding LIM protein 1 | actin binding LIM protein family, member 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity | 0.903 |
ABLIM1 | ABRA | ENSP00000338190 | ENSP00000311436 | actin binding LIM protein 1 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | 0.936 |
ABLIM1 | DCC | ENSP00000338190 | ENSP00000389140 | actin binding LIM protein 1 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | 0.907 |
ABLIM1 | FYN | ENSP00000338190 | ENSP00000346671 | actin binding LIM protein 1 | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.906 |
ABLIM1 | NCK1 | ENSP00000338190 | ENSP00000288986 | actin binding LIM protein 1 | NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA | 0.914 |
ABLIM1 | NTN1 | ENSP00000338190 | ENSP00000173229 | actin binding LIM protein 1 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.931 |
ABLIM1 | PTK2 | ENSP00000338190 | ENSP00000341189 | actin binding LIM protein 1 | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.908 |
ABLIM1 | RAC1 | ENSP00000338190 | ENSP00000348461 | actin binding LIM protein 1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.910 |
ABLIM1 | TRIO | ENSP00000338190 | ENSP00000339299 | actin binding LIM protein 1 | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.910 |
ABLIM2 | ABLIM1 | ENSP00000393511 | ENSP00000338190 | actin binding LIM protein family, member 2 | actin binding LIM protein 1 | 0.904 |
ABLIM2 | ABLIM3 | ENSP00000393511 | ENSP00000310309 | actin binding LIM protein family, member 2 | actin binding LIM protein family, member 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity | 0.905 |
ABLIM2 | ABRA | ENSP00000393511 | ENSP00000311436 | actin binding LIM protein family, member 2 | actin-binding Rho activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) | 0.936 |
ABLIM2 | DCC | ENSP00000393511 | ENSP00000389140 | actin binding LIM protein family, member 2 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | 0.906 |
ABLIM2 | FYN | ENSP00000393511 | ENSP00000346671 | actin binding LIM protein family, member 2 | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.900 |
ABLIM2 | NCK1 | ENSP00000393511 | ENSP00000288986 | actin binding LIM protein family, member 2 | NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA | 0.900 |
ABLIM2 | NTN1 | ENSP00000393511 | ENSP00000173229 | actin binding LIM protein family, member 2 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.906 |
ABLIM2 | PTK2 | ENSP00000393511 | ENSP00000341189 | actin binding LIM protein family, member 2 | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.903 |
ABLIM2 | RAC1 | ENSP00000393511 | ENSP00000348461 | actin binding LIM protein family, member 2 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.909 |
ABLIM2 | TRIO | ENSP00000393511 | ENSP00000339299 | actin binding LIM protein family, member 2 | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.910 |