node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAST | MLC1 | ENSP00000379157 | ENSP00000310375 | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | 0.900 |
CAST | PTK2 | ENSP00000379157 | ENSP00000341189 | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.927 |
CAST | TLN1 | ENSP00000379157 | ENSP00000316029 | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.941 |
MLC1 | CAST | ENSP00000310375 | ENSP00000379157 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue | 0.900 |
MLC1 | MYLK | ENSP00000310375 | ENSP00000353452 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | myosin light chain kinase | 0.956 |
MLC1 | PPP1R12B | ENSP00000310375 | ENSP00000384496 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | protein phosphatase 1, regulatory subunit 12B | 0.900 |
MLC1 | PRKACB | ENSP00000310375 | ENSP00000359719 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | protein kinase, cAMP-dependent, catalytic, beta | 0.900 |
MLC1 | PRKACG | ENSP00000310375 | ENSP00000366488 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.900 |
MLC1 | PRKAR1A | ENSP00000310375 | ENSP00000351410 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.900 |
MLC1 | PRKAR1B | ENSP00000310375 | ENSP00000353415 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.900 |
MLC1 | PTK2 | ENSP00000310375 | ENSP00000341189 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.900 |
MLC1 | ROCK1 | ENSP00000310375 | ENSP00000382697 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...] | 0.900 |
MLC1 | TLN1 | ENSP00000310375 | ENSP00000316029 | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.900 |
MYLK | MLC1 | ENSP00000353452 | ENSP00000310375 | myosin light chain kinase | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | 0.956 |
MYLK | PPP1R12B | ENSP00000353452 | ENSP00000384496 | myosin light chain kinase | protein phosphatase 1, regulatory subunit 12B | 0.575 |
MYLK | PRKACB | ENSP00000353452 | ENSP00000359719 | myosin light chain kinase | protein kinase, cAMP-dependent, catalytic, beta | 0.829 |
MYLK | PRKACG | ENSP00000353452 | ENSP00000366488 | myosin light chain kinase | protein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus | 0.804 |
MYLK | PTK2 | ENSP00000353452 | ENSP00000341189 | myosin light chain kinase | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.921 |
MYLK | TLN1 | ENSP00000353452 | ENSP00000316029 | myosin light chain kinase | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.919 |
PPP1R12B | MLC1 | ENSP00000384496 | ENSP00000310375 | protein phosphatase 1, regulatory subunit 12B | megalencephalic leukoencephalopathy with subcortical cysts 1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx | 0.900 |