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CCL8 CCL8 XCR1 XCR1 NPSR1 NPSR1 GPR68 GPR68 PTAFR PTAFR XCL2 XCL2 XCL1 XCL1 GPR132 GPR132 FPR2 FPR2 GPR4 GPR4 PLCB2 PLCB2
"XCR1" - chemokine (C motif) receptor 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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Score
XCR1chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level (333 aa)    
Predicted Functional Partners:
XCL2
chemokine (C motif) ligand 2; Chemotactic activity for lymphocytes but not for monocytes or neutrophils (By similarity) (114 aa)
        score_image score_image score_image   0.993
XCL1
chemokine (C motif) ligand 1; Chemotactic activity for lymphocytes but not for monocytes or neutrophils (114 aa)
        score_image score_image score_image   0.991
CCL8
chemokine (C-C motif) ligand 8; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8 (99 aa)
          score_image score_image   0.927
GPR4
G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production (362 aa)
          score_image score_image score_image 0.913
PLCB2
phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (1185 aa)
          score_image score_image   0.907
NPSR1
neuropeptide S receptor 1 (377 aa)
          score_image score_image score_image 0.905
GPR132
G protein-coupled receptor 132; Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication (380 aa)
          score_image score_image score_image 0.901
FPR2
formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (351 aa)
          score_image score_image score_image 0.901
GPR68
G protein-coupled receptor 68; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity) (365 aa)
          score_image score_image score_image 0.900
PTAFR
platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system (342 aa)
          score_image score_image score_image 0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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