LMAN1L protein (Homo sapiens) - STRING network view

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Score

LMAN1L

lectin, mannose-binding, 1 like (526 aa)

Predicted Functional Partners:

ZNF503-AS2

0.660

CCNY

0.603

BCAP29

0.586

TSNAX

0.583

TRAM1L1

0.573

TRAM1

0.573

TRAM2

0.573

ACVRL1

0.521

SEC23A

0.496

SEC23B

0.496

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	LMAN1L	ENSP00000373574	ENSP00000310431	activin A receptor type II-like 1; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well	lectin, mannose-binding, 1 like	0.521
BCAP29	LMAN1L	ENSP00000368414	ENSP00000310431	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	lectin, mannose-binding, 1 like	0.586
BCAP29	TSNAX	ENSP00000368414	ENSP00000355599	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis	0.607
CCNY	LMAN1L	ENSP00000363836	ENSP00000310431	cyclin Y	lectin, mannose-binding, 1 like	0.603
LMAN1L	ACVRL1	ENSP00000310431	ENSP00000373574	lectin, mannose-binding, 1 like	activin A receptor type II-like 1; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well	0.521
LMAN1L	BCAP29	ENSP00000310431	ENSP00000368414	lectin, mannose-binding, 1 like	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	0.586
LMAN1L	CCNY	ENSP00000310431	ENSP00000363836	lectin, mannose-binding, 1 like	cyclin Y	0.603
LMAN1L	SEC23A	ENSP00000310431	ENSP00000306881	lectin, mannose-binding, 1 like	Sec23 homolog A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	0.496
LMAN1L	SEC23B	ENSP00000310431	ENSP00000262544	lectin, mannose-binding, 1 like	Sec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity)	0.496
LMAN1L	TRAM1	ENSP00000310431	ENSP00000262213	lectin, mannose-binding, 1 like	translocation associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane	0.573
LMAN1L	TRAM1L1	ENSP00000310431	ENSP00000309402	lectin, mannose-binding, 1 like	translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity)	0.573
LMAN1L	TRAM2	ENSP00000310431	ENSP00000182527	lectin, mannose-binding, 1 like	translocation associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding	0.573
LMAN1L	TSNAX	ENSP00000310431	ENSP00000355599	lectin, mannose-binding, 1 like	translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis	0.583
LMAN1L	ZNF503-AS2	ENSP00000310431	ENSP00000412272	lectin, mannose-binding, 1 like	ZNF503 antisense RNA 2	0.660
SEC23A	LMAN1L	ENSP00000306881	ENSP00000310431	Sec23 homolog A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	lectin, mannose-binding, 1 like	0.496
SEC23B	LMAN1L	ENSP00000262544	ENSP00000310431	Sec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity)	lectin, mannose-binding, 1 like	0.496
TRAM1	LMAN1L	ENSP00000262213	ENSP00000310431	translocation associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane	lectin, mannose-binding, 1 like	0.573
TRAM1L1	LMAN1L	ENSP00000309402	ENSP00000310431	translocation associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (By similarity)	lectin, mannose-binding, 1 like	0.573
TRAM2	LMAN1L	ENSP00000182527	ENSP00000310431	translocation associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding	lectin, mannose-binding, 1 like	0.573
TSNAX	BCAP29	ENSP00000355599	ENSP00000368414	translin-associated factor X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	0.607

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