| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DLG5 | PCP2 | ENSP00000361467 | ENSP00000310585 | discs, large homolog 5 (Drosophila) | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.512 |
| GNAO1 | PCP2 | ENSP00000262493 | ENSP00000310585 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.543 |
| GNAO1 | PTPRU | ENSP00000262493 | ENSP00000334941 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | protein tyrosine phosphatase, receptor type, U | 0.614 |
| GNAO1 | RGS14 | ENSP00000262493 | ENSP00000386229 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | regulator of G-protein signaling 14; Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrati [...] | 0.875 |
| GNAO1 | RIC8A | ENSP00000262493 | ENSP00000325941 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) | 0.839 |
| INADL | PARD3 | ENSP00000360200 | ENSP00000363921 | InaD-like (Drosophila) | par-3 partitioning defective 3 homolog (C. elegans) | 0.753 |
| INADL | PCP2 | ENSP00000360200 | ENSP00000310585 | InaD-like (Drosophila) | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.521 |
| INSC | PARD3 | ENSP00000368872 | ENSP00000363921 | inscuteable homolog (Drosophila); May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium | par-3 partitioning defective 3 homolog (C. elegans) | 0.958 |
| INSC | PCP2 | ENSP00000368872 | ENSP00000310585 | inscuteable homolog (Drosophila); May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.710 |
| KIT | PCP2 | ENSP00000288135 | ENSP00000310585 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.576 |
| KIT | PTPRU | ENSP00000288135 | ENSP00000334941 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | protein tyrosine phosphatase, receptor type, U | 0.963 |
| PARD3 | INADL | ENSP00000363921 | ENSP00000360200 | par-3 partitioning defective 3 homolog (C. elegans) | InaD-like (Drosophila) | 0.753 |
| PARD3 | INSC | ENSP00000363921 | ENSP00000368872 | par-3 partitioning defective 3 homolog (C. elegans) | inscuteable homolog (Drosophila); May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium | 0.958 |
| PARD3 | PCP2 | ENSP00000363921 | ENSP00000310585 | par-3 partitioning defective 3 homolog (C. elegans) | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | 0.642 |
| PCP2 | DLG5 | ENSP00000310585 | ENSP00000361467 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | discs, large homolog 5 (Drosophila) | 0.512 |
| PCP2 | GNAO1 | ENSP00000310585 | ENSP00000262493 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.543 |
| PCP2 | INADL | ENSP00000310585 | ENSP00000360200 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | InaD-like (Drosophila) | 0.521 |
| PCP2 | INSC | ENSP00000310585 | ENSP00000368872 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | inscuteable homolog (Drosophila); May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium | 0.710 |
| PCP2 | KIT | ENSP00000310585 | ENSP00000288135 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinosit [...] | 0.576 |
| PCP2 | PARD3 | ENSP00000310585 | ENSP00000363921 | Purkinje cell protein 2; May function as a cell-type specific modulator for G protein-mediated cell signaling (By similarity) | par-3 partitioning defective 3 homolog (C. elegans) | 0.642 |
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