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SNRPD2 SNRPD2 LSM6 LSM6 LSM5 LSM5 LSM4 LSM4 DCP2 DCP2 LSM2 LSM2 LSM1 LSM1 LSM7 LSM7 XRN1 XRN1 PATL1 PATL1 LSM3 LSM3
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
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LSM1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA (133 aa)    
Predicted Functional Partners:
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome (103 aa)
      score_image score_image score_image score_image   0.999
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in U6 snRNP assembly and function. Binds to the 3’ end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro (91 aa)
      score_image score_image score_image score_image   0.999
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] (80 aa)
      score_image score_image score_image score_image   0.999
LSM3
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA (102 aa)
      score_image score_image score_image score_image   0.999
LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA (139 aa)
      score_image score_image score_image score_image   0.999
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (95 aa)
      score_image score_image   score_image   0.999
PATL1
protein associated with topoisomerase II homolog 1 (yeast); RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV) (770 aa)
        score_image score_image score_image   0.999
DCP2
DCP2 decapping enzyme homolog (S. cerevisiae); Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety (420 aa)
        score_image score_image score_image   0.999
XRN1
5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) (1706 aa)
        score_image score_image score_image   0.995
SNRPD2
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity) (118 aa)
      score_image score_image   score_image   0.992
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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