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SQLE SQLE CYP17A1 CYP17A1 HSD3B2 HSD3B2 SULT2B1 SULT2B1 HSD3B1 HSD3B1 HSD3B7 HSD3B7 CH25H CH25H CYP7B1 CYP7B1 CYP11A1 CYP11A1 CYP27A1 CYP27A1 STS STS
"CYP7B1" - cytochrome P450, family 7, subfamily B, polypeptide 1 in Homo sapiens
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Predicted Interactions
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CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (506 aa)    
Predicted Functional Partners:
CH25H
cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (272 aa)
       score_image score_image score_image score_image   0.986
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (369 aa)
       score_image score_image score_image score_image   0.983
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandr [...] (373 aa)
       score_image score_image score_image score_image   0.966
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (372 aa)
       score_image score_image score_image score_image   0.958
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity (531 aa)
           score_image score_image score_image 0.908
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol (365 aa)
           score_image score_image   0.904
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty (508 aa)
           score_image score_image score_image 0.901
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone (521 aa)
           score_image score_image score_image 0.901
STS
steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy (583 aa)
           score_image     0.900
SQLE
squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (574 aa)
       score_image score_image   score_image   0.888
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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