Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MRP63 | mitochondrial ribosomal protein 63 (102 aa) | ||||||||||||
Predicted Functional Partners:
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 | MRPL50 | mitochondrial ribosomal protein L50 (158 aa) |
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0.930 | |||||||||
 | MRPL38 | mitochondrial ribosomal protein L38 (380 aa) |
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0.920 | |||||||||
 | MRPL32 | mitochondrial ribosomal protein L32 (188 aa) |
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0.920 | |||||||||
 | MRPL19 | mitochondrial ribosomal protein L19 (292 aa) |
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0.913 | ||||||||||
 | MRPL15 | mitochondrial ribosomal protein L15 (296 aa) |
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0.908 | |||||||||
 | YARS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) (528 aa) |
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0.751 | ||||||||||
 | DDX28 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (540 aa) |
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0.707 | |||||||||
 | EWSR1 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (661 aa) |
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0.644 | ||||||||||
 | ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter (1545 aa) |
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0.644 | ||||||||||
 | ASPHD1 | aspartate beta-hydroxylase domain containing 1 (390 aa) |
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0.520 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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