node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG6 | GOLT1A | ENSP00000397441 | ENSP00000308535 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | golgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.575 |
COG6 | GOLT1B | ENSP00000397441 | ENSP00000229314 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | golgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.575 |
COG6 | GOSR1 | ENSP00000397441 | ENSP00000225724 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | 0.672 |
COG6 | SFT2D3 | ENSP00000397441 | ENSP00000310803 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.724 |
COG6 | STX5 | ENSP00000397441 | ENSP00000294179 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) | 0.625 |
COG6 | VTI1A | ENSP00000397441 | ENSP00000376792 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.467 |
GOLT1A | COG6 | ENSP00000308535 | ENSP00000397441 | golgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.575 |
GOLT1A | SFT2D3 | ENSP00000308535 | ENSP00000310803 | golgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.824 |
GOLT1B | COG6 | ENSP00000229314 | ENSP00000397441 | golgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.575 |
GOLT1B | SFT2D3 | ENSP00000229314 | ENSP00000310803 | golgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.824 |
GOLT1B | UBC | ENSP00000229314 | ENSP00000344818 | golgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | ubiquitin C | 0.804 |
GOSR1 | COG6 | ENSP00000225724 | ENSP00000397441 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.672 |
GOSR1 | SFT2D3 | ENSP00000225724 | ENSP00000310803 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.489 |
GOSR1 | STX5 | ENSP00000225724 | ENSP00000294179 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) | 0.999 |
GOSR1 | UBC | ENSP00000225724 | ENSP00000344818 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | ubiquitin C | 0.881 |
GOSR1 | VTI1A | ENSP00000225724 | ENSP00000376792 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.947 |
GOSR1 | YKT6 | ENSP00000225724 | ENSP00000223369 | golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] | YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity | 0.999 |
MAEL | SFT2D3 | ENSP00000356846 | ENSP00000310803 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.472 |
SFT2D3 | COG6 | ENSP00000310803 | ENSP00000397441 | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.724 |
SFT2D3 | GOLT1A | ENSP00000310803 | ENSP00000308535 | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | golgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex | 0.824 |