node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG4B | CTSF | ENSP00000384259 | ENSP00000310832 | autophagy related 4B, cysteine peptidase | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.682 |
ATG4B | GABARAPL1 | ENSP00000384259 | ENSP00000266458 | autophagy related 4B, cysteine peptidase | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | 0.994 |
ATG4B | GABARAPL2 | ENSP00000384259 | ENSP00000037243 | autophagy related 4B, cysteine peptidase | GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) | 0.990 |
CD74 | CTSF | ENSP00000009530 | ENSP00000310832 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.960 |
CD74 | CTSS | ENSP00000009530 | ENSP00000357981 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.988 |
CD74 | HLA-DRB1 | ENSP00000009530 | ENSP00000353099 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 1 | 0.915 |
CD74 | HLA-DRB5 | ENSP00000009530 | ENSP00000364114 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 5 | 0.921 |
CST4 | CTSF | ENSP00000217423 | ENSP00000310832 | cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.740 |
CST4 | CTSS | ENSP00000217423 | ENSP00000357981 | cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.818 |
CST4 | M6PR | ENSP00000217423 | ENSP00000000412 | cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively | mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex | 0.489 |
CTSF | ATG4B | ENSP00000310832 | ENSP00000384259 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | autophagy related 4B, cysteine peptidase | 0.682 |
CTSF | CD74 | ENSP00000310832 | ENSP00000009530 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.960 |
CTSF | CST4 | ENSP00000310832 | ENSP00000217423 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively | 0.740 |
CTSF | CTSS | ENSP00000310832 | ENSP00000357981 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.916 |
CTSF | GABARAPL1 | ENSP00000310832 | ENSP00000266458 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | 0.678 |
CTSF | GABARAPL2 | ENSP00000310832 | ENSP00000037243 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) | 0.621 |
CTSF | HLA-DRB1 | ENSP00000310832 | ENSP00000353099 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | major histocompatibility complex, class II, DR beta 1 | 0.900 |
CTSF | HLA-DRB5 | ENSP00000310832 | ENSP00000364114 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | major histocompatibility complex, class II, DR beta 5 | 0.900 |
CTSF | IFI30 | ENSP00000310832 | ENSP00000384886 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | interferon, gamma-inducible protein 30; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity) | 0.906 |
CTSF | M6PR | ENSP00000310832 | ENSP00000000412 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex | 0.610 |