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IFI30 IFI30 HLA-DRB1 HLA-DRB1 HLA-DRB5 HLA-DRB5 GABARAPL2 GABARAPL2 CD74 CD74 CTSF CTSF ATG4B ATG4B CTSS CTSS GABARAPL1 GABARAPL1 CST4 CST4 M6PR M6PR
"CTSF" - cathepsin F in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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CTSFcathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis (484 aa)    
Predicted Functional Partners:
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa)
        score_image score_image score_image   0.960
CTSS
cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N (331 aa)
          score_image score_image score_image 0.916
IFI30
interferon, gamma-inducible protein 30; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity) (250 aa)
          score_image score_image   0.906
HLA-DRB5
major histocompatibility complex, class II, DR beta 5 (266 aa)
          score_image     0.900
HLA-DRB1
major histocompatibility complex, class II, DR beta 1 (266 aa)
          score_image     0.900
CST4
cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively (141 aa)
            score_image   0.740
ATG4B
autophagy related 4B, cysteine peptidase (393 aa)
            score_image   0.682
GABARAPL1
GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles (117 aa)
      score_image     score_image   0.678
GABARAPL2
GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) (117 aa)
      score_image     score_image   0.621
M6PR
mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (277 aa)
            score_image   0.610
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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