| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ELF5 | FGF7 | ENSP00000311010 | ENSP00000267843 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | 0.824 |
| ELF5 | MUC4 | ENSP00000311010 | ENSP00000417498 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | mucin 4, cell surface associated | 0.802 |
| ELF5 | NOTCH1 | ENSP00000311010 | ENSP00000277541 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.739 |
| ELF5 | NOTCH2 | ENSP00000311010 | ENSP00000256646 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | notch 2 | 0.695 |
| ELF5 | NOTCH3 | ENSP00000311010 | ENSP00000263388 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.713 |
| ELF5 | NOTCH4 | ENSP00000311010 | ENSP00000364163 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | notch 4 | 0.708 |
| ELF5 | PRL | ENSP00000311010 | ENSP00000302150 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | prolactin; Prolactin acts primarily on the mammary gland by promoting lactation | 0.832 |
| ELF5 | STAT5A | ENSP00000311010 | ENSP00000341208 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | 0.934 |
| ELF5 | STAT5B | ENSP00000311010 | ENSP00000293328 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | 0.927 |
| ELF5 | WFDC5 | ENSP00000311010 | ENSP00000361875 | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | WAP four-disulfide core domain 5; Putative acid-stable proteinase inhibitor | 0.816 |
| FGF7 | ELF5 | ENSP00000267843 | ENSP00000311010 | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | 0.824 |
| FGF7 | NOTCH1 | ENSP00000267843 | ENSP00000277541 | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.582 |
| FGF7 | NOTCH2 | ENSP00000267843 | ENSP00000256646 | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | notch 2 | 0.437 |
| FGF7 | NOTCH3 | ENSP00000267843 | ENSP00000263388 | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.436 |
| FGF7 | NOTCH4 | ENSP00000267843 | ENSP00000364163 | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | notch 4 | 0.442 |
| MUC4 | ELF5 | ENSP00000417498 | ENSP00000311010 | mucin 4, cell surface associated | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | 0.802 |
| NOTCH1 | ELF5 | ENSP00000277541 | ENSP00000311010 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | E74-like factor 5 (ets domain transcription factor); Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation | 0.739 |
| NOTCH1 | FGF7 | ENSP00000277541 | ENSP00000267843 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation | 0.582 |
| NOTCH1 | NOTCH3 | ENSP00000277541 | ENSP00000263388 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.961 |
| NOTCH1 | NOTCH4 | ENSP00000277541 | ENSP00000364163 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | notch 4 | 0.913 |
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