ABCC12 protein (Homo sapiens) - STRING network view

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ABCC12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity) (1359 aa)

Predicted Functional Partners:

PRRT2

0.861

VCPIP1

0.740

MRPS7

0.720

UBC

0.648

TOP2A

0.544

TOP2B

0.544

LONP2

0.540

GSR

0.522

ABCF3

0.522

TXNRD2

0.519

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC12	ABCF3	ENSP00000311030	ENSP00000411471	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	ATP-binding cassette, sub-family F (GCN20), member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B (By similarity)	0.522
ABCC12	GSR	ENSP00000311030	ENSP00000221130	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	glutathione reductase; Maintains high levels of reduced glutathione in the cytosol	0.522
ABCC12	LONP2	ENSP00000311030	ENSP00000285737	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	0.540
ABCC12	MRPS7	ENSP00000311030	ENSP00000245539	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	mitochondrial ribosomal protein S7	0.720
ABCC12	PRRT2	ENSP00000311030	ENSP00000351608	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	proline-rich transmembrane protein 2	0.861
ABCC12	TOP2A	ENSP00000311030	ENSP00000411532	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	topoisomerase (DNA) II alpha 170kDa	0.544
ABCC12	TOP2B	ENSP00000311030	ENSP00000396704	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.544
ABCC12	TXNRD2	ENSP00000311030	ENSP00000383365	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	thioredoxin reductase 2	0.519
ABCC12	UBC	ENSP00000311030	ENSP00000344818	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	ubiquitin C	0.648
ABCC12	VCPIP1	ENSP00000311030	ENSP00000309031	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	valosin containing protein (p97)/p47 complex interacting protein 1; Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity)	0.740
ABCF3	ABCC12	ENSP00000411471	ENSP00000311030	ATP-binding cassette, sub-family F (GCN20), member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B (By similarity)	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	0.522
ABCF3	MRPS7	ENSP00000411471	ENSP00000245539	ATP-binding cassette, sub-family F (GCN20), member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B (By similarity)	mitochondrial ribosomal protein S7	0.401
ABCF3	UBC	ENSP00000411471	ENSP00000344818	ATP-binding cassette, sub-family F (GCN20), member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B (By similarity)	ubiquitin C	0.799
GSR	ABCC12	ENSP00000221130	ENSP00000311030	glutathione reductase; Maintains high levels of reduced glutathione in the cytosol	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	0.522
GSR	TOP2A	ENSP00000221130	ENSP00000411532	glutathione reductase; Maintains high levels of reduced glutathione in the cytosol	topoisomerase (DNA) II alpha 170kDa	0.509
GSR	TOP2B	ENSP00000221130	ENSP00000396704	glutathione reductase; Maintains high levels of reduced glutathione in the cytosol	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.502
GSR	UBC	ENSP00000221130	ENSP00000344818	glutathione reductase; Maintains high levels of reduced glutathione in the cytosol	ubiquitin C	0.744
LONP2	ABCC12	ENSP00000285737	ENSP00000311030	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	ATP-binding cassette, sub-family C (CFTR/MRP), member 12; Probable transporter (By similarity)	0.540
LONP2	TOP2A	ENSP00000285737	ENSP00000411532	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	topoisomerase (DNA) II alpha 170kDa	0.510
LONP2	TOP2B	ENSP00000285737	ENSP00000396704	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene	0.510

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