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STRINGSTRING
NUMB NUMB IRS1 IRS1 CD200 CD200 CD200R1 CD200R1 C1orf146 C1orf146 TNFRSF11A TNFRSF11A
"CD200R1" - CD200 receptor 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD200R1CD200 receptor 1 (348 aa)    
Predicted Functional Partners:
CD200
CD200 molecule; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (294 aa)
        score_image score_image score_image   0.999
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells (616 aa)
            score_image   0.610
NUMB
numb homolog (Drosophila) (651 aa)
            score_image   0.560
C1orf146
chromosome 1 open reading frame 146 (180 aa)
            score_image   0.499
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) (1242 aa)
            score_image   0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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