node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA2 | CCNB1 | ENSP00000274026 | ENSP00000256442 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.993 |
CCNA2 | CCNB2 | ENSP00000274026 | ENSP00000288207 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.972 |
CCNA2 | CDK1 | ENSP00000274026 | ENSP00000378699 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNA2 | CDK2 | ENSP00000274026 | ENSP00000266970 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNA2 | CDK3 | ENSP00000274026 | ENSP00000400088 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1 [...] | 0.992 |
CCNA2 | CDKN1B | ENSP00000274026 | ENSP00000228872 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | 0.999 |
CCNA2 | CKS1B | ENSP00000274026 | ENSP00000311083 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | CDC28 protein kinase regulatory subunit 1B; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.992 |
CCNA2 | CUL1 | ENSP00000274026 | ENSP00000326804 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | 0.819 |
CCNA2 | SKP1 | ENSP00000274026 | ENSP00000231487 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.928 |
CCNA2 | SKP2 | ENSP00000274026 | ENSP00000274255 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and [...] | 0.998 |
CCNB1 | CCNA2 | ENSP00000256442 | ENSP00000274026 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.993 |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CDK1 | ENSP00000256442 | ENSP00000378699 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNB1 | CDK2 | ENSP00000256442 | ENSP00000266970 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNB1 | CDK3 | ENSP00000256442 | ENSP00000400088 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1 [...] | 0.997 |
CCNB1 | CDKN1B | ENSP00000256442 | ENSP00000228872 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry | 0.848 |
CCNB1 | CKS1B | ENSP00000256442 | ENSP00000311083 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | CDC28 protein kinase regulatory subunit 1B; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.968 |
CCNB1 | CUL1 | ENSP00000256442 | ENSP00000326804 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | 0.795 |
CCNB1 | SKP1 | ENSP00000256442 | ENSP00000231487 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.722 |
CCNB1 | SKP2 | ENSP00000256442 | ENSP00000274255 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and [...] | 0.847 |