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SERF1B SERF1B FSTL5 FSTL5 FSTL4 FSTL4 WFIKKN2 WFIKKN2 BMP4 BMP4 GDF11 GDF11 BMP2 BMP2 FST FST NTSR1 NTSR1 TGFB1 TGFB1 MSTN MSTN
"WFIKKN2" - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity) (576 aa)    
Predicted Functional Partners:
GDF11
growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (407 aa)
        score_image   score_image   0.974
MSTN
myostatin; Acts specifically as a negative regulator of skeletal muscle growth (375 aa)
        score_image   score_image   0.807
NTSR1
neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system (418 aa)
            score_image   0.750
FST
follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) (344 aa)
            score_image   0.661
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
        score_image   score_image   0.577
FSTL5
follistatin-like 5 (847 aa)
            score_image   0.561
TGFB1
transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (390 aa)
        score_image   score_image   0.522
SERF1B
small EDRK-rich factor 1B (centromeric) (110 aa)
            score_image   0.502
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
        score_image   score_image   0.500
FSTL4
follistatin-like 4 (842 aa)
            score_image   0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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