CTSW protein (Homo sapiens) - STRING network view

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CTSW

cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity (376 aa)

Predicted Functional Partners:

CST4

0.750

M6PR

0.680

ZBTB7B

0.464

CAD

0.425

SNF8

0.404

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAD	CTSW	ENSP00000264705	ENSP00000311300	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	0.425
CST4	CTSW	ENSP00000217423	ENSP00000311300	cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	0.750
CST4	M6PR	ENSP00000217423	ENSP00000000412	cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively	mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex	0.489
CTSW	CAD	ENSP00000311300	ENSP00000264705	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)	0.425
CTSW	CST4	ENSP00000311300	ENSP00000217423	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively	0.750
CTSW	M6PR	ENSP00000311300	ENSP00000000412	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex	0.680
CTSW	SNF8	ENSP00000311300	ENSP00000421380	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly [...]	0.404
CTSW	ZBTB7B	ENSP00000311300	ENSP00000292176	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	zinc finger and BTB domain containing 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repre [...]	0.464
M6PR	CST4	ENSP00000000412	ENSP00000217423	mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex	cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively	0.489
M6PR	CTSW	ENSP00000000412	ENSP00000311300	mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	0.680
SNF8	CTSW	ENSP00000421380	ENSP00000311300	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly [...]	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	0.404
ZBTB7B	CTSW	ENSP00000292176	ENSP00000311300	zinc finger and BTB domain containing 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repre [...]	cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity	0.464

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